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The Amniotic Fluid Proteome Differs Significantly between Donor and Recipient Fetuses in Pregnancies Complicated by Twin-to-Twin Transfusion Syndrome

Kim SM, Cho BK, Kim BJ, Lee HY, Norwitz ER, Kang MJ, Lee SM, Park CW, Jun JK, Yi EC, Park JS

BACKGROUND: Twin-to-twin transfusion syndrome (TTTS) is a serious complication of monochorionic twin pregnancies. It results from disproportionate blood supply to each fetus caused by abnormal vascular anastomosis within the placenta....
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Prognostic factors in hepatocellular carcinoma patients with bone metastases

Kim S, Choi Y, Kwak DW, Lee HS, Hur WJ, Baek YH, Lee SW

PURPOSE: To identify the prognostic factors that could influence survival and to compare prognoses of the patients with the number of the risk factors that might assist in the adequate...
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Hepatocellular carcinoma surveillance in the 21st century: Saving lives or causing harm?

Hanouneh I, Alkhouri N, Singal AG

Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death worldwide. Prognosis and treatment options largely depend on tumor stage at diagnosis, with curative treatments only available...
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A Rare Case of Lymph Node Metastasis from Early Gastric Cancer

Yoshikawa , Kadokawa Y, Ohana M, Fukuda A, Seno H

Gastric cancers that fulfill the Japanese criteria for curative endoscopic resection show a low risk of lymph node (LN) metastasis. Here, we report a case of LN metastasis from early...
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Hemorrhagic extrahepatic recurrence of hepatocellular carcinoma: A case report

Yeow GP, Yeow DG, Sankaran P, Maiyauen T, Sharif MS

The recurrence of hepatocellular carcinoma (HCC) can mainly be divided into two phases or types: the intrahepatic recurrence (IHR) and the extrahepatic recurrence (EHR). Generally speaking, the EHR is usually...
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Appropriate treatment modality for solitary small hepatocellular carcinoma: Radiofrequency ablation vs. resection vs. transplantation?

Ahn KS, Kang KJ

There has been controversy regarding the first-line treatment modality for the patients who have small solitary hepatocellular carcinoma (HCC); radiofrequency ablation (RFA) or percutaneous ethanol injection (PEI), surgical hepatic resection...
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Transarterial Chemolipiodolization for Hepatocellular Carcinoma with Central Bile Duct Invasion Causing Conjugated Hyperbilirubinemia: Safety and Prognostic Factors for Survival

Yang K, Sung PS, Oh JS, Chun HJ, Jang JW, Bae SH, Choi JY, Yoon SK

BACKGROUND/AIMS: The treatments and outcomes of hepatocellular carcinoma (HCC) with bile duct invasion are not well known. We aimed to confirm the safety of transarterial chemolipiodolization (TACL) and identify prognostic...
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Continuing five or more locoregional therapies before living donor salvage liver transplantation for hepatocellular carcinoma is related to poor recurrence-free survival

Rhu J, Kim JM, Choi GS, Kwon CH, Joh JW

PURPOSE: This study was designed to analyze factors related to the success of salvage liver transplantation (SLT) in hepatocellular carcinoma (HCC). While liver resection (LR) is considered the best locoregional...
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Predictors of post-hepatectomy liver failure in patients undergoing extensive liver resections for hepatocellular carcinoma

Chin KM, Allen JC, Teo JY, Kam JH, Tan EK, Koh Y, Goh BK, Cheow PC, Raj P, Chow KH, Chung YF, Ooi LL, Chan CY, Lee SY

BACKGROUNDS/AIMS: To determine the prevalence of post-hepatectomy liver failure/insufficiency (PHLF/I) in patients undergoing extensive hepatic resections for hepatocellular carcinoma (HCC) and to assess the predictive value of preoperative factors for...
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Synergistic effect of metformin on sorafenib in in vitro study using hepatocellular carcinoma cell lines

Chung YG, Tak E, Hwang S, Lee JY, Kim JY, Kim YY, Song GW, Lee KJ, Kim N

BACKGROUNDS/AIMS: Hepatocellular carcinoma (HCC) recurrence remains a great concern following hepatic resection and liver transplantation. We investigated the metformin-induced cytotoxic effects on sorafenib in an in vitro study using HCC...
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Relationship Between Serum Tumor-related Markers and Dietary Intakes in Korean Healthy Adults

Kim MH, Choi MK

The purpose of this study was to investigate the relationship between serum tumor markers and dietary intakes in healthy adults to address a nutrition guide for cancer prevention. We analyzed...
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Annual Report on the External Quality Assessment Scheme for Tumor Markers in Korea (2017)

Song SH

In 2017, the tumor marker program of the Korean Association of External Quality Assessment Service was performed for tumor markers I and II. Tumor marker I comprised alpha-fetoprotein (AFP), carcinoembryonic...
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Analytical Performance of New ARCHITECT AFP Assay: Comparison with the Current Assay

Woo KS, An GD, Lim HH, Han JY

Alpha-fetoprotein (AFP) is frequently used for hepatocellular carcinoma (HCC) diagnosis and surveillance. Although the current ARCHITECT AFP (List number 7K67) assay range is 0–350 ng/mL, all samples with test results...
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Angiomyolipoma of the Liver without a Fat Component, Mimicking a Hepatocellular Carcinoma

Woo YM, Ryu SH, Min JW, Kim MR, Park TY, Moon JS, Kang YK

Angiomyolipoma (AML) is a rare benign mesenchymal tumor in the liver, which is composed of blood vessels, smooth muscle, and adipose cells. The proportion of each component varies, making a...
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A Case of Combined Hepatocellular-cholangiocarcinoma Mimicking Pyogenic Liver Abscess

Baek SS, Yoon EL, Kim HJ, Bae KE, Park K, Choi WC

Heterogeneous features of liver cancer can mimic liver abscess. Therefore it is essential to double-check tumor markers in the diagnosis of liver abscess. Herein, we report a case of combined...
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Liver lesions detected in a hepatitis B core total antibody-positive patient masquerading as hepatocellular carcinoma: a rare case of peliosis hepatis and a review of the literature

Tan CH, Soon GS, Kow WC

Peliosis Hepatis (PH) is a rare vascular disorder of the liver, characterized by the presence of cystic blood-filled cavities distributed throughout the hepatic parenchyma. The pathogenesis of PH remains controversial....
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Predictors of Micrometastases in Patients with Barcelona Clinic Liver Cancer Classification B Hepatocellular Carcinoma

Suh SW, Choi YS

PURPOSE: Transarterial chemoembolization (TACE) is indicated for Barcelona Clinic Liver Cancer (BCLC) B hepatocellular carcinoma (HCC). Whether TACE provides any long-term survival benefits remains unclear. We aimed to investigate micrometastases...
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Clinical features and outcomes of patients with hepatocellular carcinoma complicated with bile duct invasion

An J, Lee KS, Kim KM, Park DH, Lee SS, Lee D, Shim JH, Lim YS, Lee HC, Chung YH, Lee YS

BACKGROUND/AIMS: Little is known about the treatment or outcomes of hepatocellular carcinoma (HCC) complicated with bile duct invasion. METHODS: A total of 247 consecutive HCC patients with bile duct invasion at...
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A comparative study of sorafenib and metronomic chemotherapy for Barcelona Clinic Liver Cancer-stage C hepatocellular carcinoma with poor liver function

Yang H, Woo HY, Lee SK, Han JW, Jang B, Nam HC, Lee HL, Lee SW, Song DS, Song MJ, Oh JS, Chun HJ, Jang JW, Lozada A, Bae SH, Choi JY, Yoon SK

BACKGROUND/AIMS: Metronomic chemotherapy (MET) is frequently administered in comparatively low doses as a continuous chemotherapeutic agent. The aim of this study was to evaluate the feasibility and overall survival (OS)...
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Predictive Factors for Complete Response and Recurrence after Transarterial Chemoembolization in Hepatocellular Carcinoma

Jeong SO, Kim EB, Jeong SW, Jang JY, Lee SH, Kim SG, Cha SW, Kim YS, Cho YD, Kim HS, Kim BS, Kim YJ, Goo DE, Park SY

BACKGROUND/AIMS: To investigate the predictive factors for complete response (CR) and recurrence after CR in patients with hepatocellular carcinoma (HCC) treated with transarterial chemoembolization (TACE). METHODS: Among 691 newly diagnosed HCC...
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