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Molecular Mechanism of the G2/M Arrest in Breast Cancer Cell Lines (T47D and MDA-MB231) Induced by Genistein

Park JY, Kang KS, Sohn YK

PURPOSE: To analyze the effect of the growth control on human breast cancer cells with genistein treatment and to investigate the mechanism of genistein-induced G2/M arrest in T47D and MDA-MB231...
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The Significance of p53 and K-ras Immunocytochemical Staining in the Diagnosis of Malignant Biliary Obstruction by Brush Cytology during ERCP

Kim YS, Kim HG, Han J, Hur CJ, Kim BS, Jung JT, Kwon JG, Kim EY, Cho CH, Sohn YK

  • KMID: 2284189
  • Gut Liver.
  • 2010 Jun;4(2):219-225.
BACKGROUND/AIMS: Brush cytology during ERCP can provide a pathologic diagnosis in malignant biliary obstruction. K-ras and p53 mutations are commonly found in biliary and pancreatic cancers. We evaluated the diagnostic...
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Prognostic Analysis According to N Stage and Circumferential Resection Margin in Patients with Locally Advanced Rectal Cancer

Sohn YK, Shin JY, Hong KH

PURPOSE: Efforts must be made to clarify the contribution of lymph node metastasis (NM) to adjuvant (chemo) radiotherapy following a curative resection for rectal cancer as the circumferential resection margin...
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Availability of Immunohistochemistry in the Diagnosis of Follicular Variant of Papillary Thyroid Carcinoma

Jeong JY, Jang JS, Sohn YK, Jung JH, Chun YK, Park JY

  • KMID: 2277623
  • Korean J Pathol.
  • 2010 Feb;44(1):48-55.
BACKGROUND: Making the diagnosis of the follicular variant of papillary thyroid carcinoma (FVPTC) is often difficult, and there are no accurate immunohistochemical or molecular markers. The purpose of this study...
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The effect of erythropoietin in neonatal rat model of hypoxic-ischemic brain injury

Kim HM, Choe BH, Kwon SH, Sohn YK

PURPOSE: Perinatal asphyxia is an important cause of neonatal mortality and subsequent lifelong neurodevelopmental handicaps. Although many treatment strategies have been tested, there is currently no clinically effective treatment to...
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Changes related term alteration of pediatrics and roles of pediatrician

Sohn YK

The ultimate goal of the term alteration to pediatrics is that not only infants and children but also adlescents are subjet to pediatrics. At 27, June, 2007 the term pediatrics...
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The association between adverse pregnancy outcomes and the serum inhibin A levels in mid-trimester of gestation

Oh HM, Kim SY, Lee SP, Sohn YK, Lee GH, Kim JM

  • KMID: 2273518
  • Korean J Obstet Gynecol.
  • 2008 Nov;51(11):1239-1244.
OBJECTIVES: To investigate the association between abnormal inhibin-A level in Quad test during the 15 and 18 weeks of gestation and adverse pregnancy outcomes. METHODS: From January 2005 to March 2007,...
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Inactivation of TPEF Gene by Aberrant Methylation in Hepatocellular Carcinoma

Chung WB, Kim SY, Chun SY, Kang KS, Lee HA, Kim JO, Park JY, Sohn YK, Kim JW

  • KMID: 1163279
  • Korean J Pathol.
  • 2008 Feb;42(1):9-15.
BACKGROUND: Abnormalities of genomic methylation patterns have been shown to play a role in the development of carcinoma, and the silencing of tumor suppressor genes is related to local...
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Genistein Induces G2/M Cell Cycle Arrest and Apoptosis in Rat Neuroblastoma B35 Cells; Involvement of p21(waf1/cip1), Bax and Bcl-2

Ismail IA, Kang KS, Kim JW, Sohn YK

  • KMID: 1640304
  • Korean J Pathol.
  • 2006 Oct;40(5):339-347.
BACKGROUND: The effect of genistein on different types of cells has been investigated. However, its effect on the nervous system is still unclear. The aim of the present work is...
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Tumor-Like Presentation of Organized Chronic Subdural Hematoma

Youn DK, Sohn YK, Park J

  • KMID: 2339835
  • J Korean Neurosurg Soc.
  • 2006 Sep;40(3):199-201.
An organizing hematoma with tumor-like presentation in association with a chronic subdural hematoma(CSDH) has not been reported. Most reported cases of an intracranial mass in association with a CSDH have...
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Effects of Selective Cyclooxygenase-2 Inhibitor NS-398 Pretreatment on the Rat Spinal Cord after Contusion Injury

Cheong HD, Sung JK, Ham IS, Kang KS, Kim JO, Kim JW, Park TI, Sohn YK

  • KMID: 2277651
  • Korean J Pathol.
  • 2006 Aug;40(4):255-262.
BACKGROUND: Secondary spinal cord injury (SCI) that follows an initial mechanical insult can exacerbate the overall damage, limit the restorative processes and eventually lead to an in- creased neurological deficit....
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Prognostic Implication of Associated Cleft Palate in Patients with Cleft Lip

Jung JY, Hong JS, Kim HJ, Sohn YK, Shim SS, Park JS, Jun JK, Yoon BH, Syn HC

  • KMID: 2280570
  • Korean J Perinatol.
  • 2006 Jun;17(2):195-203.
OBJECTIVE: The objective of this study is to compare the pregnancy outcomes and postnatal developmental problems according to the types of cleft lip and/or palate, and to evaluate the increase...
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Perinatal Outcomes of Triplet Pregnancies

Chae SJ, Yoo WJ, Kang KH, Kim BJ, Lee SE, Sohn YK, Shim SS, Park JS, Jun JK, Yoon BH, Syn HC

  • KMID: 2141697
  • Korean J Obstet Gynecol.
  • 2006 May;49(5):1051-1059.
OBJECTIVE: To evaluate the perinatal outcomes and maternal complications associated with triplet pregnancies. METHODS: Medical records of consecutive triplet pregnancies delivered in ( )( )Hospital from 1997 to 2005 were...
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A Case of Intracranial Cavernous Hemangioma Diagnosed in Pregnancy

Kang JH, Lee SM, Park HE, Park CW, Sohn YK, Shim SS, Park JS, Jun JK, Yoon BH, Syn HC

  • KMID: 2272829
  • Korean J Obstet Gynecol.
  • 2006 Apr;49(4):910-914.
The cavernous hamangioma is a relatively rare intracranial vascular malformation and generally asymptomatic, Seizure is the most common clinical presentation and the hemorrhage is the second. Because reproductive females have...
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Eisenmenger syndrome in pregnancy at second and third trimester

Kang KH, Kim BJ, Sohn YK, Lee SE, Kim MK, Shim SS, Park JS, Jun JK, Yoon BH, Syn HC

  • KMID: 2272819
  • Korean J Obstet Gynecol.
  • 2006 Apr;49(4):831-839.
OBJECTIVE: Because women with Eisenmenger syndrome are counseled strongly not to conceive, pregnancy cases with Eisenmenger syndrome are rare in clinical situation. We performed this study to analyze pregnancies at...
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Glutathione S-transferases (GSTM1, GSTT1 and GSTP1) and N-acetyltransferase 2 Polymorphisms and the Risk of Gastric Cancer

Hong SH, Kim JW, Kim HG, Park IK, Ryoo JW, Lee CH, Sohn YK, Lee JY

  • KMID: 792400
  • J Prev Med Public Health.
  • 2006 Mar;39(2):135-140.
OBJECTIVES: Polymorphisms of genes from glutathione Stransferases (GSTs) and N-acetyltransferase 2 (NAT2) have been associated with increased susceptibility to various cancers. Previous results showed that East Asians such as...
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Use of real-time quantitative PCR to identify high expressed genes in head and neck squamous cell carcinoma cell lines

Lee YG, Chun SY, Lee HA, Sohn YK, Kang KS, Kim JO, Yun SM, Kim JW, Jang HJ

  • KMID: 2190364
  • J Korean Assoc Oral Maxillofac Surg.
  • 2006 Feb;32(1):69-75.
Head and neck squamous cell carcinoma(HNSCC) is the sixth most common cancer among men in the developed world affecting the tongue, pharynx, larynx and oral cavity. HNSCC is thought to...
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Effects of Genistein and Daidzein on the Growth of Human Colon Cancer HCT-116 Cells

Shin JH, Kang KS, Kim JO, Yoon GS, Kwon TG, Kim JW, Sohn YK

  • KMID: 1593161
  • Korean J Pathol.
  • 2006 Feb;40(1):46-51.
BACKGROUND: Genistein and daidzein are two major soybean isoflavones. They have received increasing attention because of their possible roles for cancer prevention. However, their mechanisms of action and molecular targets...
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The Role of Inducible Nitric Oxide Synthase Following Spinal Cord Injury in Rat

Kwak EK, Kim JW, Kang KS, Lee YH, Hua QH, Park TI, Park JY, Sohn YK

Acute spinal cord injury (SCI) is two-step process that first involves the primary mechanical injury and then the secondary injury is induced by various biochemical reactions. Apoptosis is one of...
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DNA Hypermethylation of Tumor-Related Genes in Gastric Carcinoma

Hong SH, Kim HG, Chung WB, Kim EY, Lee JY, Yoon SM, Kwon JG, Sohn YK, Kwak EK, Kim JW

The hypermethylation of the CpG islands is a common mechanism for the inactivation of tumor-related genes. In the present study, we analyzed the methylation status of genes for cell repair...
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