Korean J Obstet Gynecol.  2007 May;50(5):776-783.

Effects of laparoscopic surgery on the immune system of the patients with gynecologic diseases

• You SH
• Yoon JH
• Shin EY
• Lew YO
• Kim DH

Abstract

OBJECTIVE
Elective surgical approaches and trauma cause changes in the production of different cytokines. The aim of this study was to evaluate the effects of laparoscopic surgery on the immune system of patients with gynecologic diseases.
METHODS
We recruited the open surgery group (n=20) and laparoscopic surgery group (n=33). In a prospective study we examined the C-reactive protein (CRP) level, the production of the cytokines Interleukin-1beta (IL-1beta), Interleukin-6 (IL-6), Interleukin-8 (IL-8), Interleukin-10 (IL-10) and TNF-alpha concentrations by ELISA. In addition the fibrinogen, transferrin, albumin, hemoglobin and hematocrit were measured. Statistical analysis was made by Mann-Whitney U test and Kruskal-Wallis test.
RESULTS
There were significant statistical differences in the CRP, IL-6 and IL-8 between the open surgery group and laparoscopic surgery group after surgery. The CRP and IL-8 showed a more distinct increase in open surgery group 24 hours after surgery, the differences between the two surgical approaches were significant (p<0.05).
CONCLUSION
Elective surgical approaches cause changes in the immune system, which can be evaluated by the reaction of cytokines. Laparoscopic surgery cause less activation of the CRP and IL-8 than open surgery.

Keyword

C-reactive protein; Cytokines

MeSH Terms

C-Reactive Protein
Cytokines
Enzyme-Linked Immunosorbent Assay
Female
Fibrinogen
Genital Diseases, Female*
Hematocrit
Humans
Immune System*
Interleukin-10
Interleukin-1beta
Interleukin-6
Interleukin-8
Laparoscopy*
Prospective Studies
Transferrin
Tumor Necrosis Factor-alpha
C-Reactive Protein
Cytokines
Fibrinogen
Interleukin-10
Interleukin-1beta
Interleukin-6
Interleukin-8
Transferrin
Tumor Necrosis Factor-alpha