Korean J Obes.
2005 Jun;14(2):94-100.
Effects of Voglibose and Glimepiride on Body weight in Patients with Type 2 Diabetes.
- Affiliations
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- 1Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Korea. lkw65@ajou.ac.kr
- 2Department of Family practice and Community health, Ajou University School of Medicine, Suwon, Korea.
- 3Department of Family Medicine, Chungnam National University Hospital, Daejeon, Korea.
- 4Department of Internal Medicine, Ulsan University College of Medicine, Seoul, Korea.
- 5Department of Internal Medicine, College of Medicine, Soonchunhyang University, Korea.
- 6Department of Internal Medicine, Yonsei University College of Medicine, Seoul Korea.
- 7Department of Internal Medicine, Catholic University of Daegu, School of Medicine, Daegu, Korea.
- 8Center of Obesity, Nutrition and Meabolism, Pusan National University Hospital, Pusan, Korea.
- 9Department of Internal Medicine, Hanyang University Guri Hospital, Korea.
- 10Department of Internal Medicine, College of Medicine Inha University, Incheon, Korea.
Abstract
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BACKGROUND: Obesity is a major risk factor for type 2 diabetes. Improvement in glycemic control using insulin, sulfonylurea and meglitinide is often accompanied by weight gain. But metformin and alpha-glucosidase inhibitor have a positive effect(decrease) on weight. In this study, we compared the effect of voglibose, glimepiride, and diet alone on body weight and glycemic control after a period of 12 weeks.
METHODS
The patients with type 2 diabetes were randomly assigned to one of the following three treatment groups: Patients treated for 12 weeks with voglibose, those treated with glimepiride and those with diet alone. Anthropometric parameters and metabolic parameters were measured at the initial stage and after 12 weeks. The study consisted of 448 patients with type 2 diabetes. There were 223 patients in the voglibose group, 176 in the glimepiride group, and 49 in the diet alone group.
RESULTS
The patients treated with voglibose and diet alone showed higher decreased body weight compared with glimepiride group (voglibose vs glimepiride, P=0.001; diet vs glimepiride, P=0.016). In contrast, glimepiride group showed more decreased HbA1C compared with voglibose and diet alone groups(glimepiride vs voglibose, P=0.001; glimepiride vs diet, P=0.004).
CONCLUSION
Voglibose showed more effective on body weight reduction despite the relatively weak glycemic control compared with glimepiride.
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