Blood Res.  2013 Sep;48(3):222-225. 10.5045/br.2013.48.3.222.

A case of myelodysplastic syndrome with marked eosinophilia showing favorable prognosis

• Kim MJ
• Bae SH
• Lee AJ
• Kim SG

• KMID: 2270710
• DOI: http://doi.org/10.5045/br.2013.48.3.222

Abstract

Myelodysplastic syndrome (MDS) with eosinophilia is a rare condition and has yet to be classified under the 2008 World Health Organization classification. However, reports have described the prognostic significance of chronic persistent eosinophilia in MDS. Here, we report a case of a 67-year-old woman who was admitted to the hospital in July 2007 with generalized weakness, dizziness, and dyspnea on exertion persisting for 5 years. In the initial investigation, eosinophilia (22.1%) in peripheral blood and an increased proportion of eosinophils (5.6%) in normocellular bone marrow with dysplastic megakaryocytes and erythroid cells were noted. Eosinophilia was continuously detected during follow-up over 3 years. In a second bone marrow examination in August 2010, hypercellular bone marrow with similar features was observed. These findings led to the diagnosis of MDS with chronic persistent eosinophilia. To increase awareness of the prognostic significance of MDS with chronic eosinophilia, here we report a slow-progressing case of MDS with chronic persistent eosinophilia lasting over 6 years.

Keyword

Myelodysplastic syndrome; Eosinophilia; Prognosis

MeSH Terms

Aged
Bone Marrow
Bone Marrow Examination
Dizziness
Dyspnea
Eosinophilia
Eosinophils
Erythroid Cells
Female
Follow-Up Studies
Humans
Megakaryocytes
Myelodysplastic Syndromes
Prognosis
World Health Organization

Figure

• 

  Fig. 1 Bone marrow (BM) aspirate smears showing dyserythropoiesis (A), dysmegakaryopoiesis (B), and increased promyelocytes with eosinophilic granules (C) in the initial BM study performed in July 2007. At a follow-up examination in August 2012, a BM aspirate smear showed increased immature eosinophils in the promyelocyte stage (D) (Wright stain, ×1,000).

• 

  Fig. 2 High eosinophilia counts in peripheral blood were seen during the follow-up over 6 years (from July 2007 to June 2012).

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