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POEMS Syndrome: Bone Marrow, Laboratory, and Clinical Findings in 24 Korean Patients

Shim H, Seol CA, Park CJ, Cho YU, Seo EJ, Lee JH, Yoon DH, Suh CW, Park SH, Jang S

POEMS syndrome is a rare paraneoplastic syndrome, which includes polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes due to plasma cell (PC) neoplasm. Diagnosis of this disease is challenging because of...
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CRISPR/Cas9-mediated knockout of Rag-2 causes systemic lymphopenia with hypoplastic lymphoid organs in FVB mice

Kim JI, Park JS, Kim H, Ryu SK, Kwak J, Kwon E, Yun JW, Nam KT, Lee HW, Kang BC

Recombination activating gene-2 (RAG-2) plays a crucial role in the development of lymphocytes by mediating recombination of T cell receptors and immunoglobulins, and loss of RAG-2 causes severe combined immunodeficiency...
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A Sporadic Case of Epstein Syndrome: A Rare Cause of Refractory Thrombocytopenia

Song KM, Song H, Jeong DH, Lee J, Noh SM, Lee BH, Lee KH

A 37-year-old female presented to our hospital with a history of bleeding episodes (excessive bleeding after tooth extraction, gum bleeding, easy bruising, and excessive menstruation) and severe thrombocytopenia (2,000/µL). She...
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Advances in Treatment for Polycythemia Vera and Essential Thrombocythemia

Kim SY

Although there have been substantial advances in confirming diagnoses and defining the molecular characteristics of polycythemia vera (PV) and essential thrombocythemia (ET), treatments for these conditions remain elementary. The main...
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Successful Treatment of Relapsed Acquired Amegakaryocytic Thrombocytopenia with Repeat Cyclosporine

Bae SY, Han TH, Sohn BS, Oh HH, Choi SJ, Park M, Yuh YJ

Acquired amegakaryocytic thrombocytopenia (AAMT) is an unusual disease characterized by severe thrombocytopenia resulting from a marked decrease in bone marrow megakaryocytes. Various pathogenic mechanisms have been suggested, and several treatments...
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Cryptic Insertion of the BCR Gene at 9q34 in Philadelphia-Negative Chronic Myelogenous Leukaemia

Kim HJ, Ji M, Kim H, Moon HW, Hur M, Yun YM

Chronic myelogenous leukaemia (CML) is a myeloproliferative neoplasm that is almost always characterised by the presence of t(9;22)(q34;q11.2). Approximately 5% to 10% of CML patients lack cytogenetic evidence of t(9;22)(q34;q11.2)...
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Apoptosis: role in myeloid cell development

Sarvothaman S, Undi RB, Pasupuleti SR, Gutti U, Gutti RK

Hematopoiesis is the process that generates blood cells in an organism from the pluripotent stem cells. Hematopoietic stem cells are characterized by their ability to undergo self-renewal and differentiation. The...
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A Case of Pentasomy 21 With Two Isochromosome 21s in Acute Megakaryoblastic Leukemia Associated With Down Syndrome

Park Y, Lim J, Ko YH, Kim J, Kwon GC, Koo SH

No abstract available.
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A Case of Essential Thrombocythemia in a Patient with Ankylosing Spondylitis Concomitantly Treated with Adalimumab

Lee DS, Lee SG, Shin HJ, Lee SH, Park EK, Na HJ, Park CH, Park JH, Han IS, Kim GT

Extreme thrombocytosis in patients with ankylosing spondylitis (AS) is rarely reported. Because the relationship between high disease activity and increased platelet counts is somewhat contradictory, severe thrombocytosis in AS patients...
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Genome-Wide Association Study Identifies Candidate Loci Associated with Platelet Count in Koreans

Oh JH, Kim YK, Moon S, Kim YJ, Kim BJ

Platelets are derived from the fragments that are formed from the cytoplasm of bone marrow megakaryocytes-small irregularly shaped anuclear cells. Platelets respond to vascular damage, contracts blood vessels, and attaches...
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A Case of Immune Thrombocytopenic Purpura Associated with Preexisting Ulcerative Colitis Treated with Colectomy and Splenectomy

Kwon JH, Lee C, Choi JM, Han YM, Choi YH, Lee JY, Yoon H, Chun J, Park KJ, Im JP, Kim SG, Kim JS, Jung HC

Ulcerative colitis is a chronic inflammatory bowel disease of unknown etiology, associated with extraintestinal manifestations, including the rarely reported immune thrombocytopenic purpura. Here, we present a case of immune thrombocytopenic...
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A case of myelodysplastic syndrome with marked eosinophilia showing favorable prognosis

Kim MJ, Bae SH, Lee AJ, Kim SG

Myelodysplastic syndrome (MDS) with eosinophilia is a rare condition and has yet to be classified under the 2008 World Health Organization classification. However, reports have described the prognostic significance of...
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Manifestation of Giant Bilateral Symptomatic Adrenal Myelolipomas in an Adult Patient with Congenital Adrenal Hyperplasia

Kim YM, Choi JH, Lee BH, Kim GH, Hong BS, Ryu YJ, Yoo HW

Adrenal myelolipoma is an uncommon non-functioning tumor that is composed of variable amounts of mature adipose tissue and scattered islands of hematopoietic elements, including erythroid, myeloid, lymphoid series, and megakaryocytes....
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The Treatment of Pernicious Anemia in Children with Graves' Disease

Yoo JK, Yang S, Shim YS, Song JS

Organ specific autoimmune diseases may occur in the same individual. Type III polyglandular autoimmune disease is defined by the occurrence in the same individual of two or more of the...
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NDRG2 Promotes GATA-1 Expression through Regulation of the JAK2/STAT Pathway in PMA-stimulated U937 Cells

Kang K, Jung H, Nam S, Lim JS

BACKGROUND: N-myc downstream-regulated gene 2 (NDRG2), a member of a newly described family of differentiation-related genes, has been characterized as a regulator of dendritic cells. However, the role of NDRG2...
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A Case of Concomitant Inv(3)(q21q26) and Cryptic BCR/ABL1 Rearrangement in the Blast Crisis of Chronic Myeloid Leukemia

Lee H, Cho C, Kwon MJ, Nam MH, Lee CK, Kim YK

  • KMID: 2312184
  • Lab Med Online.
  • 2011 Jul;1(3):163-167.
Structural abnormalities of the long arm of chromosome 3 (3q) have been associated with elevated platelet count and hyperplasia of megakaryocytes with dysplasia in various hematological malignancies. Some cases of...
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Gametocytes of Plasmodium falciparum in the megakaryocytes

Chandra H, Chandra S

No abstract available.
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Autologous peripheral blood stem cell transplantation with high-dose therapy for anaplastic large cell lymphoma with progressive myelofibrosis

Lee NR, Song EK, Yhim HY, Jang KY, Choi SI, Yim CY, Kwak JY

  • KMID: 2081818
  • Korean J Med.
  • 2010 Jul;79(1):77-81.
Myelofibrosis is a myeloproliferative neoplasm characterized by abnormal bone marrow megakaryocyte proliferation with reticulin and collagen fibrosis, leukoerythroblastosis, anemia, increased level of serum lactate dehydrogenase and splenomegaly. Myelofibrosis associated with...
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Acquired Amegakaryocytic Thrombocytopenia after Thymectomy in a Case of Pure Red Cell Aplasia Associated with Thymoma

Cho AR, Cha YJ, Kim HR, Park EK, Cha EJ

The association of thymoma with pure red cell aplasia has been well documented, but amegakaryocytic thrombocytopenia is not a recognized paraneoplastic syndrome complicating thymoma. We report a case of thymoma-complicated...
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A Case of Post-Essential Thrombocythemia Myelofibrosis with Severe Osteosclerosis

Lee KK, Cho HI, Chi HS, Kim DY, Chae SL, Huh HJ

Essential thrombocythemia (ET) is a chronic myeloproliferative neoplasm that involves primarily the megakaryocytic lineage. After many years, a few patients with ET may develop bone marrow (BM) fibrosis and rarely...
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