Yeungnam Univ J Med.  1991 Dec;8(2):209-216. 10.12701/yujm.1991.8.2.209.

Acute megakaryoblastic leukemia

Abstract

Acute megakaryoblastic leukemia is a rare and rapidly fatal disease characterized by proliferation of megakaryocyte series and atypical megakaryocytes in the bone marrow. Acute megakaryoblastic leukemia is suspicious when 1) megakaryocyte in peripheral blood, mixture of large and small mononuclear megakaryoblast in the bone marrow 2) cytoplasmic budding in blast 3) myelofibrosis (dense medullary overgrowth of reticulin fibers) 4) PAS (+), ANAE (+), SBB (−), peroxidase (−) and which is confirmed by platelet peroxidase oxidation on electron microscope or monoclonal antibody. A case of acute megakaryoblastic leukemia was studied morphologically and monoclonal antibody.

Keyword

Acute megakaryoblastic leukemia; Monoclonal antibody

MeSH Terms

Blood Platelets
Bone Marrow
Cytoplasm
Leukemia, Megakaryoblastic, Acute*
Megakaryocyte Progenitor Cells
Megakaryocytes
Naphthol AS D Esterase
Peroxidase
Primary Myelofibrosis
Reticulin
Naphthol AS D Esterase
Peroxidase
Reticulin
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