Yonsei Med J.  1977 Jun;18(1):34-44. 10.3349/ymj.1977.18.1.34.

Light and Electron Microscopic Studies of Megakaryocytes in Korean Epidemic Hemorrhagic Fever

• Lee YB
• Kim CS
• Lee KK

• KMID: 687732
• DOI: http://doi.org/10.3349/ymj.1977.18.1.34

Abstract

Light and electron microscopic studies of megakaryocytes in bone marrow from 14 cases of Korean epidemic hemorrhagic fever were made, together with clinical manifestations, laboratory findings, and changes in other marrow elements. The number of megakaryocytes increased in various degree from patient to patient, with a shift to the left of maturation gradation. Cytoplasms were markedly smaller but granularity was fairly good. The most constant finding was marked decrease or complete absence of platelet formation at the periphery of the cytoplasm. Ultrastructurally, there was a marked decrease of the cisternal system in the cytoplasm and lack of cleavage line. No virus particles or active degenerative process was noted. These changes of the megakaryocytes are similar to those reported in idiopathic thrombocytopenic purpura, indicating that megakaryocytic changes in Korean epidemic hemorrhagic fever are likely secondary to thrombocytopenia which was caused by other Mechanism.

MeSH Terms

Adult
Aged
Bone Marrow/pathology
Female
Hemorrhagic Fever with Renal Syndrome/pathology*
Human
Male
Megakaryocytes/ultrastructure*
Middle Age