J Korean Med Sci.  1999 Aug;14(4):448-450. 10.3346/jkms.1999.14.4.448.

Myelodysplastic syndrome that progressed to acute myelomonocytic leukemia with eosinophilia showing peculiar chromosomal abnormality: a case report

• Kim SH
• Suh CW
• Choi SJ
• Kim JG
• Lee JH
• Kim SB
• Kim SW
• Lee KH
• Lee JS
• Kim WK
• Kim SH
• Seo EJ
• Chi HS

• KMID: 1731321
• DOI: http://doi.org/10.3346/jkms.1999.14.4.448

Abstract

Myelodysplastic syndrome is a closely related group of acquired bone marrow disorders characterized by ineffective and dysplastic hematopoiesis. These clonal disorders frequently progress to acute leukemia. Acute myelomonocytic leukemia with eosinophilia is characterized by an increase in abnormal eosinophils in the bone marrow, relatively good clinical course and inv (16) chromosomal abnormality. We experienced one case of refractory anemia with excess blasts which progressed to refractory anemia with excess blasts in transformation and finally to acute myelomonocytic leukemia with eosinophilia showing peculiar chromosomal abnormalities of der (1;7).

Keyword

Myelodysplastic syndromes; Leukemia, myelomonocytic, acute; Eosinophilia; Chromosome abnormalities

MeSH Terms

Adult
Anemia/pathology
Anemia/genetics
Anemia/etiology
Bone Marrow/pathology
Case Report
Chromosomes, Human, Pair 16*
Disease Progression
Eosinophilia/pathology
Eosinophilia/genetics*
Eosinophilia/etiology
Human
Inversion (Genetics)*
Karyotyping
Leukemia, Myelocytic, Acute/pathology
Leukemia, Myelocytic, Acute/genetics*
Leukemia, Myelocytic, Acute/etiology
Male
Myelodysplastic Syndromes/pathology
Myelodysplastic Syndromes/genetics*
Myelodysplastic Syndromes/complications