Korean J Nutr.  2003 Jul;36(6):570-576.

Protectins Effects of Vitamin E against Immobilization Stress-Induced Oxidative Damage in Rat Brain

• Park MH
• Kang SM
• Jung HY
• Hong SG

Abstract

The remarkable change of phenomenon induced by stress increase energy metabolism that can induce many reactive oxygen species (ROS) production. ROS can peroxidize cellular macromolecules including lipid and protein. The object of this study was to investigate whether stress may induce cellular damage by producing ROS and whether vitamin E, as a strong lipid-soluble antioxidant, can protect cells against reactive oxygen species produced by noise and immobilization stress in SD rats. The stress group increased 5-hydroxyindole aceti acid (5-HIAA) , one of the stress hormone, in brain tissue and free fatty acid in plasma. Vitamin I treatment had no effect on 5-HIAA but free fatty acid contents decreased with a fortified vitamin I diet. Furthermore, the body weight of vitamin I-treated rats increased more than that of the stress group. Lipid peroxidation and protein degradation as an index of oxidative damage in brain tissue decreased with the use of the fortified vitamin I diet supplement. The results suggest that vitamin I supplements have a protective effect against noise and immobilization stress-induced oxidative damage in brain tissue.

Keyword

stress; oxidativ damage; brain; antioxidant; vitamin E

MeSH Terms

Animals
Antigens, CD59*
Body Weight
Brain*
Diet
Energy Metabolism
Hydroxyindoleacetic Acid
Immobilization*
Lipid Peroxidation
Noise
Plasma
Proteolysis
Rats*
Reactive Oxygen Species
Vitamin E*
Vitamins*
Antigens, CD59
Hydroxyindoleacetic Acid
Reactive Oxygen Species
Vitamin E
Vitamins