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Agreement and Reliability between Clinically Available Software Programs in Measuring Volumes and Normative Percentiles of Segmented Brain Regions

Song H, Lee SA, Jo SW, Chang SK, Lim Y, Yoo YS, Kim JH, Choi SH, Sohn CH

Objective: To investigate the agreement and reliability of estimating the volumes and normative percentiles (N%) of segmented brain regions among NeuroQuant (NQ), DeepBrain (DB), and FreeSurfer (FS) software programs, focusing...
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Brain Metabolic Network Redistribution in Patients with White Matter Hyperintensities on MRI Analyzed with an Individualized Index Derived from 18F-FDG-PET/MRI

Ma J, Hua XY, Zheng MX, Wu JJ, Huo BB, Xing XX, Gao X, Zhang H, Xu JG

Objective: Whether metabolic redistribution occurs in patients with white matter hyperintensities (WMHs) on magnetic resonance imaging (MRI) is unknown. This study aimed 1) to propose a measure of the brain...
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A rare additional lobe of cerebellum, projecting from its superior surface

Nayak SB, Sumalatha S, Shetty SD

Human cerebellum plays a vital role in motor coordination, regulation of muscle tone and maintaining the equilibrium of the body. It seldom shows anatomical/morphological variations. Herein, we report the presence...
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Profile and Outcome of Management of Brain Tumours in Kaduna Northwestern Nigeria

Danjuma S, Dauda HA, Kene AI, Akau KS, Jinjiri IN

Objective : Tumours of the brain are a rare occurrence accounting for approximately 2% of all neoplasms in adults. Few studies have been done in Nigeria on the profile of...
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Association of Nucleus Basalis of Meynert Functional Connectivity and Cognition in Idiopathic Rapid-Eye-Movement Sleep Behavior Disorder

Byun JI, Cha KS, Kim M, Lee WJ, Lee HS, Sunwoo JS, Shin JW, Kim TJ, Jun JS, Kim HJ, Shin WC, Schenck CH, Lee SK, Jung KY

Background and Purpose Cognitive impairments are common in isolated rapid-eye-movement sleep behavior disorder (iRBD), in which the cholinergic system may play an important role. This study aimed to characterize the...
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Variations of Resting-State EEG-Based Functional Networks in Brain Maturation From Early Childhood to Adolescence

Chung YG, Jeon Y, Kim RG, Cho A, Kim H, Hwang H, Choi J, Kim KJ

Background and Purpose Alterations in human brain functional networks with maturation have been explored extensively in numerous electroencephalography (EEG) and functional magnetic resonance imaging studies. It is known that the...
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Mild Traumatic Brain Injury and Subsequent Acute Pulmonary Inflammatory Response

Lim SH, Jung H, Youn DH, Kim TY, Han SW, Kim BJ, Lee JJ, Jeon JP

Objective : The influence of moderate-to-severe traumatic brain injury (TBI) on acute pulmonary injury is well established, but the association between acute pulmonary injury and mild TBI has not been...
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Neuromodulation for Trigeminal Neuralgia

Chung M, Huh R

Clinical studies on neuromodulation intervention for trigeminal neuralgia have not yet shown promising results. This might be due to the fact that the pathophysiology of chronic trigeminal neuropathy is not...
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Case Series of Isolated Deep Gray Matter Injuries in Preterm Infants

Hong KT, Shin SH, Choi YH, Kim EK, Kim HS

Hypoxic-ischemic encephalopathy in neonates is an important cause of brain damage that leads to severe neurological sequelae or death. Brain injury patterns on magnetic resonance imaging (MRI) scans are used...
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Blood-brain Barrier Damage is Pivotal for SARS-CoV-2 Infection to the Central Nervous System

Rodríguez-Morales J, Guartazaca-Guerrero S, Rizo-Téllez SA, Viurcos-Sanabria R, Barrón EV, Hernández-Valencia AF, Nava P, Escobedo G, Carrillo-Ruiz JD, Méndez-García LA

  • KMID: 2532837
  • Exp Neurobiol.
  • 2022 Aug;31(4):270-276.
  • doi: 10.5607/en21049
Transsynaptic transport is the most accepted proposal to explain the SARS-CoV-2 infection of the CNS. Nevertheless, emerging evidence shows that neurons do not express the SARS-CoV-2 receptor ACE2, which highlights...
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Evaluation of Changes in Peripheric Biomarkers Related to Blood Brain Barrier Damage in Patients with Schizophrenia and Their Correlation with Symptoms

Yazla E, Kayadibi H, Cetin I, Aydinoglu U, Karadere ME

Objective: The aim of the study was to evaluate the levels of peripheric biomarkers that have been associated with blood brain barrier (BBB) damage in healthy controls and two groups...
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Quantitative Susceptibility Mapping of Brain Iron Deposition in Patients With Recurrent Depression

Duan X, Xie Y, Zhu X, Chen L, Li F, Feng G, Li L

Objective Recurrence is the most significant feature of depression and the relationship between iron and recurrent depression is still lack of direct evidence in vivo. Methods Twenty-one patients with depression and...
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Donation after Circulatory Death in Lung Transplantation

Hyun S, Haam S

The shortage of donor lungs has become a serious obstacle to implementing lung transplantation (LTx). Donation after circulatory death (DCD) donors are among the several donor pools utilized to overcome...
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IntraBrain Injector (IBI): A StereotacticGuided Device for Repeated Delivery of Therapeutic Agents Into the Brain Parenchyma

Lee J, Lee S, Jung W, Kim GB, Kim T, Seong J, Jang H, Noh Y, Lee NK, Lee BR, Lee JI, Choi SJ, Oh W, Kim N, Lee S, Na DL

Background: To deliver therapeutics into the brain, it is imperative to overcome the issue of the blood-brain-barrier (BBB). One of the ways to circumvent the BBB is to administer therapeutics...
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Survival Outcomes and Predictors for Recurrence of Surgically Treated Brain Metastasis From Non-Small Cell Lung Cancer

Byun J, Kim JH, Kim M, Lee S, Kim YH, Hong CK, Kim JH

Background There are numerous factors to consider in deciding whether to undergo surgical treatment for brain metastasis from lung cancer. Herein, we aimed to analyze the survival outcome and predictors...
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Recent Update on Neurosurgical Management of Brain Metastasis

Yoo J, Park HH, Kang SG, Chang JH

Brain metastasis (BM), classified as a secondary brain tumor, is the most common malignant central nervous system tumor whose median overall survival is approximately 6 months. However, the survival rate...
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Managing Side Effects of Cytotoxic Chemotherapy in Patients With High Grade Gliomas

Ha H, Lim JH

Cytotoxic chemotherapy has been a mainstay of cancer treatment since the 1940s. In the recent era of emergent targeted therapies and immunotherapies, many cytotoxic chemotherapy agents including temozolomide are still...
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Local Drug Delivery Strategies for Glioblastoma Treatment

Cha GD, Jung S, Choi SH, Kim DH

Glioblastoma multiforme (GBM) is a brain tumor notorious for its malignancy. The key reason for the limited efficacy of standard treatment is the high recurrence rate of GBM, even after...
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Cerebral Metastases in Appendiceal Cancer: Comprehensive Review and Report of Rare Medullary Carcinoma Histology

Mackel C, Rosenberg H, Varma H, Vega R, Stippler M

Appendiceal cancer is an extremely rare malignancy, and its metastatic spread to the brain is even more unusual. We describe a 47-year-old female who presented with a rare cerebral appendiceal...
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The ability of orexin-A to modify pain-induced cyclooxygenase-2 and brain-derived neurotrophic factor expression is associated with its ability to inhibit capsaicin-induced pulpal nociception in rats

Shahsavari F, Abbasnejad M, Esmaeili-Mahani S, Raoof M

Background: The rostral ventromedial medulla (RVM) is a critical region for the management of nociception. The RVM is also involved in learning and memory processes due to its relationship with...
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