Ann Dermatol.
2013 Nov;25(4):479-482. 10.5021/ad.2013.25.4.479.
Extensive Psoriasis Induced by Pegylated Interferon Alfa-2a and Ribavirin in the Treatment of Chronic Hepatitis C
- Affiliations
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- 1Department of Dermatology, Pusan National University School of Medicine, Yangsan, Korea. hcko@pusan.ac.kr
- 2Bio-medical Research Institute, Pusan National University Hospital, Busan, Korea.
- 3Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.
- KMID: 2265062
- DOI: http://doi.org/10.5021/ad.2013.25.4.479
Abstract
- A 56-year-old man with chronic hepatitis C was treated with pegylated interferon alfa-2a in combination with ribavirin. However, psoriatic lesions appeared and worsened dramatically during therapy. Because of the extensive skin eruptions, he stopped therapy for chronic hepatitis C and subsequently started narrow-band ultraviolet B phototherapy and topical calcipotriol/betamethasone dipropionate ointment. After this, the psoriasis improved in a slow but comprehensive manner. Our case suggests that physicians should keep in mind the possibility of psoriasis as a side effect of interferon treatment for chronic hepatitis C.
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