Korean J Med.  2011 Dec;81(6):740-750.

The Anti-Inflammatory Effects of Statin in 5/6 Nephrectomized Rats

• Park MY
• Choi SJ
• Kim JK
• Hwang SD

Abstract

BACKGROUND/AIMS
In a previous study, statin therapy reduced proteinuria and ameliorated the progression of chronic kidney disease. However, in patients with chronic renal failure (CRF), the beneficial effect of statin therapy on the preservation of renal function has not been determined. Thus, we determined the effect of rosuvastatin on CRF.
METHODS
Male Sprague-Dawley rats (6 weeks old) were subjected to 5/6 nephrectomy. Six weeks after the procedure, the rats were divided into control and rosuvastatin-treated groups. Body weight and blood/urine biochemical parameters were measured 6 weeks after 5/6 nephrectomy and 8 weeks after the start of rosuvastatin treatment. Remnant kidneys were harvested at 6 (n = 4) and 14 (n = 8) weeks after 5/6 nephrectomy.
RESULTS
During rosuvastatin treatment, changes in body weight and serum total and low-density lipoprotein cholesterol did not differ significantly between the control and rosuvastatin-treated groups. Although serum creatinine and proteinuria increased in both groups, the differences were not significant (p = 0.24 and 0.77, respectively). Immunohistochemical staining, enzyme-linked immunosorbent assays, and western blotting showed that the expression of transforming growth factor-beta1 and intracellular adhesion molecule-1 were reduced in the rosuvastatin-treated group.
CONCLUSIONS
Long-term statin treatment may attenuate the inflammatory process in the progression of renal failure.

Keyword

HMG-CoA reductase inhibitor; Chronic renal failure; 5/6 nephrectomy

MeSH Terms

Animals
Blotting, Western
Body Weight
Cholesterol
Creatinine
Enzyme-Linked Immunosorbent Assay
Fluorobenzenes
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Kidney
Kidney Failure, Chronic
Lipoproteins
Male
Nephrectomy
Proteinuria
Pyrimidines
Rats
Rats, Sprague-Dawley
Renal Insufficiency
Renal Insufficiency, Chronic
Sulfonamides
Rosuvastatin Calcium
Cholesterol
Creatinine
Fluorobenzenes
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Lipoproteins
Pyrimidines
Sulfonamides