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Are Statins Beneficial for Patients With Heart Failure?

Pyun WB

There is a tremendous amount of evidence about the beneficial roles of statins, as related to primary and secondary prevention, for patients with ischemic heart disease. Many cardiologists are prescribing...
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The Anti-Inflammatory Effects of Statin in 5/6 Nephrectomized Rats

Park MY, Choi SJ, Kim JK, Hwang SD

  • KMID: 2264156
  • Korean J Med.
  • 2011 Dec;81(6):740-750.
BACKGROUND/AIMS: In a previous study, statin therapy reduced proteinuria and ameliorated the progression of chronic kidney disease. However, in patients with chronic renal failure (CRF), the beneficial effect of statin...
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Effect of Additional Statin Therapy on Endothelial Function and Prognosis in Patients With Vasospastic Angina

Yun KH, Shin IS, Park EM, Rhee SJ, Lee EM, Yoo NJ, Kim NH, Oh SK, Jeong JW

BACKGROUND AND OBJECTIVES: Vasospastic angina is correlated with endothelial dysfunction. We compared endothelial function using flow-mediated vasodilatation (FMD) and circulating endothelial progenitor cells (EPCs) between patients with vasospasm and those...
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Cost-effectiveness of the Use of Statins in the Korean Population

Han KH, Kim HJ, Kim JJ

OBJECTIVE: Statins reduce risk of cardiovascular disease through lowering of LDL-C (Low Density Lipoprotein cholesterol). We analyzed cost-effectiveness of statins in the reduction of serum LDL-C level among Korean population...
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Rosuvastatin Does Not Affect Fasting Glucose, Insulin Resistance, or Adiponectin in Patients with Mild to Moderate Hypertension

Kim W, Hong MJ, Woo JS, Kang WY, Hwang SH, Kim W

The effects of statins on insulin resistance and new-onset diabetes are unclear. The purpose of this study was to evaluate the effects of rosuvastatin on insulin resistance and adiponectin in...
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Impact of High-Dose Statin Pretreatment in Patients with Stable Angina during Off-Pump Coronary Artery Bypass

Youn YN, Park SY, Hwang Y, Joo HC, Yoo KJ

  • KMID: 2288823
  • Korean J Thorac Cardiovasc Surg.
  • 2011 Jun;44(3):208-214.
BACKGROUND: Periprocedural treatment with high-dose statins is known to have cardioprotective and pleiotropic effects, such as anti-thrombotic and anti-inflammatory actions. We aimed to assess the efficacy of high-dose rosuvastatin loading...
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Effect of Statins on C-reactive Protein, Lipoprotein(a) and Fibrinogen in Hypercholesterolemic Patients

Cho JH, Kim KJ, Lee WS, Lee KJ, Kim SW, Kim TH, Kim CJ

OBJECTIVE: C-reactive protein (CRP), lipoprotein (a)[Lp(a)], and fibrinogen are associated with systemic inflammatory reactions. Statins have anti-inflammatory effects. However, the effect of statins on these parameters is inconsistent. We evaluated...
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Reversible Dysphasia and Statins

Davies GR

This paper presents a case of reversible dysphasia occurring in a patient prescribed atorvastatin in combination with indapamide. A milder dysphasia recurred with the prescription of rosuvastatin and was documented...
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HMG-CoA Reductase Inhibitor Improves Endothelial Dysfunction in Spontaneous Hypertensive Rats Via Down-regulation of Caveolin-1 and Activation of Endothelial Nitric Oxide Synthase

Suh JW, Choi DJ, Chang HJ, Cho YS, Youn TJ, Chae IH, Kim KI, Kim CH, Kim HS, Oh BH, Park YB

Hypertension is associated with endothelial dysfunction and increased cardiovascular risk. Caveolin-1 regulates nitric oxide (NO) signaling by modulating endothelial nitric oxide synthase (eNOS). The purpose of this study was to...
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Effect of Early Statin Therapy on Circulating Endothelial Progenitor Cells During the Acute Phase in Patients With Acute Myocardial Infarction

Choi JH, Oh SK, Yun KH, Shin IS, Kim SH, Lee AS, Park EM, Rhee SJ, Yoo NJ, Lee EM, Kim NH, Jeong JW

BACKGROUND AND OBJECTIVES: The mobilization of circulating endothelial progenitor cells (EPCs) might represent a useful strategy for the clinical therapy of ischemic heart disease. We examined the effect of early...
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Factors of Compliance in Patients with Hypercholesterolemia Using Rosuvastatin in Primary Care

Kim HY, Lee JA, Kim YS, Sunwoo S, Oh HJ, Kim CS, Yum K, Choi C, Jeong YS, Song SW, Kim DH, Kim YS

BACKGROUND: In order to evaluate the factors of compliance with a lipid lowering therapy, a prospective observational study of patients with hypercholesterolemia using rosuvastatin was carried out. METHODS: A total of...
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The Effects of Rosuvastatin on Plaque Regression in Patients Who Have a Mild to Moderate Degree of Coronary Stenosis With Vulnerable Plaque

Hong YJ, Jeong MH, Chung JW, Sim DS, Cho JS, Yoon NS, Yoon HJ, Moon JY, Kim KH, Park HW, Kim JH, Ahn Y, Cho JG, Park JC, Kang JC

BACKGROUND AND OBJECTIVES: Intensive lipid-lowering therapy with statins improves the clinical outcomes and patient survival and it reduces the progression of atherosclerosis. Intravascular ultrasound (IVUS) has been used for calculating...
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Comparative Study of Low Doses of Rosuvastatin and Atorvastatin on Lipid and Glycemic Control in Patients with Metabolic Syndrome and Hypercholesterolemia

Park JS, Kim YJ, Choi JY, Kim YN, Hong TJ, Kim DS, Kim KY, Jeong MH, Chae JK, Oh SK, Seong IW

BACKGROUND/AIMS: This multicenter, open-labeled, randomized trial was performed to compare the effects of rosuvastatin 10 mg and atorvastatin 10 mg on lipid and glycemic control in Korean patients with nondiabetic...
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