Korean J Intern Med.  2010 Mar;25(1):27-35. 10.3904/kjim.2010.25.1.27.

Comparative Study of Low Doses of Rosuvastatin and Atorvastatin on Lipid and Glycemic Control in Patients with Metabolic Syndrome and Hypercholesterolemia

• Park JS
• Kim YJ
• Choi JY
• Kim YN
• Hong TJ
• Kim DS
• Kim KY
• Jeong MH
• Chae JK
• Oh SK
• Seong IW

• KMID: 1785651
• DOI: http://doi.org/10.3904/kjim.2010.25.1.27

Abstract

BACKGROUND/AIMS
This multicenter, open-labeled, randomized trial was performed to compare the effects of rosuvastatin 10 mg and atorvastatin 10 mg on lipid and glycemic control in Korean patients with nondiabetic metabolic syndrome.
METHODS
In total, 351 patients who met the modified National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria for metabolic syndrome with low-density lipoprotein cholesterol (LDL-C) levels > or = 130 mg/dL were randomized to receive either rosuvastatin 10 mg (n = 173) or atorvastatin 10 mg (n = 178) for over 6 weeks.
RESULTS
After 6 weeks of treatment, greater reductions in total cholesterol (- 35.94 +/- 11.38 vs. - 30.07 +/- 10.46%, p < 0.001), LDL-C (48.04 +/- 14.45 vs. 39.52 +/- 14.42%, p < 0.001), non-high-density lipoprotein cholesterol (- 42.93 +/- 13.15 vs. - 35.52 +/- 11.76%, p < 0.001), and apolipoprotein-B (- 38.7 +/- 18.85 vs. - 32.57 +/- 17.56%, p = 0.002) levels were observed in the rosuvastatin group as compared to the atorvastatin group. Overall, the percentage of patients attaining the NCEP ATP III goal was higher with rosuvastatin as compared to atorvastatin (87.64 vs. 69.88%, p < 0.001). Changes in glucose and insulin levels, and homeostasis model assessment of insulin resistance index were not significantly different between the two groups. The safety and tolerability of the two agents were similar.
CONCLUSIONS
Rosuvastatin 10 mg was more effective than atorvastatin 10 mg in achieving NCEP ATP III LDL-C goals in patients with nondiabetic metabolic syndrome, especially in those with lower NCEP ATP III target level goals.

Keyword

Metabolic syndrome X; Hypercholesterolemia; Rosuvastatin; Atorvastatin

MeSH Terms

Blood Glucose/metabolism
Cholesterol, LDL/blood
Female
Fluorobenzenes/*administration & dosage
Hemoglobin A, Glycosylated/metabolism
Heptanoic Acids/*administration & dosage
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors/*administration & dosage
Hypercholesterolemia/blood/complications/*drug therapy
Hyperglycemia/blood/complications/*drug therapy
Insulin/blood
Male
Metabolic Syndrome X/blood/complications/*drug therapy
Middle Aged
Pyrimidines/*administration & dosage
Pyrroles/*administration & dosage
Sulfonamides/*administration & dosage
Treatment Outcome