Biomol Ther.  2016 Mar;24(2):171-177. 10.4062/biomolther.2015.089.

Effect of Coenzyme Q10 Supplementation in Statin-Treated Obese Rats

• Choi HK
• Won EK
• Choung SY

• KMID: 2170529
• DOI: http://doi.org/10.4062/biomolther.2015.089

Abstract

Statins, HMG-CoA reductase inhibitors, are known to cause serious muscle injuries (e.g. myopathy, myositis and rhabdomyolysis), and these adverse effects can be rescued by co-administration of coenzyme Q10 (CoQ10) with statins. The goal of the current research is to assess the efficacy of combined treatment of CoQ10 with Atorvastatin for hyperlipidemia induced by high-fat diet in SD rats. 4-week-old Sprague-Dawley male rats were fed normal diet or high-fat diet for 6 weeks. Then, rats were treated with either Statin or Statin with various dosages of CoQ10 (30, 90 or 270 mg/kg/day, p.o.) for another 6 weeks. Compared to Statin only-treatment, CoQ10 supplementation significantly reduced creatine kinase and aspartate aminotransferase levels in serum which are markers for myopathy. Moreover, CoQ10 supplementation with Statin further reduced total fat, triglycerides, total cholesterol, and low-density lipoprotein-cholesterol. In contrast, the levels of high-density lipoprotein-cholesterol and CoQ10 were increased in the CoQ10 co-treated group. These results indicate that CoQ10 treatment not only reduces the side effects of Statin, but also has an anti-obesity effect. Therefore an intake of supplementary CoQ10 is helpful for solving problem of obese metabolism, so the multiple prescription of CoQ10 makes us think a possibility that can be solved in being contiguous to the obesity problem, a sort of disease of the obese metabolism.

Keyword

Statins; Coenzyme Q10; Hyperlipidemia; HMG-CoA reductase; Myopathy

MeSH Terms

Animals
Aspartate Aminotransferases
Cholesterol
Creatine Kinase
Diet
Diet, High-Fat
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hyperlipidemias
Male
Metabolism
Muscular Diseases
Myositis
Obesity
Oxidoreductases
Prescriptions
Rats*
Rats, Sprague-Dawley
Triglycerides
Atorvastatin Calcium
Aspartate Aminotransferases
Cholesterol
Creatine Kinase
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Oxidoreductases
Triglycerides