Clin Psychopharmacol Neurosci.  2024 Aug;22(3):484-492. 10.9758/cpn.23.1150.

Synergistic Effect of Coenzyme Q10 and L-Carnitine on Gliosis and Anhedonia, in a Rat Model of Multiple Sclerosis: An Immunohistochemical Study

• Qureshi T
• Ali S
• Fahad T

• KMID: 2559168
• DOI: http://doi.org/10.9758/cpn.23.1150

Abstract

Objective
This study provides histological evidence of the combined effects of L-Carnitine, and Coenzyme Q10 on gliosis and anhedonia in a rat model of multiple sclerosis (MS).
Methods
Fifty male Sprague Dawley rats were randomly divided into 5 groups of 10 rats each. Group 1 was the control group. The rest of the groups were disease models and were given 0.2% cuprizone w/w to induce MS. After 4 weeks, Group 3 started receiving L-Carnitine, Group 4 was given Coenzyme Q10, and Group 5 received both, while cuprizone poisoning continued. After 12 weeks sucrose preference test and tail suspension test were performed for anhedonia. Rats were euthanized and brains were dissected, and assessed for astrocytes, oligodendrocytes, and microglial count.
Results
A significant increase in oligodendrocyte count, while a reduction in astrocyte and microglial count was seen in the synergistic group (p ＜ 0.05). Synergism could not be proved in anhedonia.
Conclusion
The combination of Coenzyme Q10 and L-Carnitine has a synergistic effect in controlling gliosis in a rat model of MS, but synergism could not be demonstrated on anhedonia.

Keyword

Multiple sclerosis; Cuprizone; Carnitine; Coenzyme Q10; Gliosis