Korean J Neuromuscul Disord.
2021 Jun;13(1):15-19. 10.46518/kjnmd.2021.13.1.15.
Statin-Naïve Paraneoplastic Anti-HMGCR Myopathy
- Affiliations
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- 1Department of Neurology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea
- KMID: 2518423
- DOI: http://doi.org/10.46518/kjnmd.2021.13.1.15
Abstract
- Anti-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (anti-HMGCR) myopathy is a subtype of immune-mediated necrotizing myopathy regardless of exposure to statins. Necrotizing myopathy is distinguished by necrotic muscle fibers with a relative lack of inflammation. It is frequently associated with a high risk of permanent muscle damage and disability. Recent studies have suggested a slightly increased risk of cancer in patients with anti-HMGCR myopathy. This report describes a case of statin-naïve paraneoplastic anti-HMGCR myopathy, with rapidly progressive muscle weakness leading to respiratory failure.
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