Korean J Neuromuscul Disord.
2021 Dec;13(2):64-66. 10.46518/kjnmd.2021.13.2.64.
Statin-Induced Immune-Mediated Necrotizing Myopathy with Anti-HMGCR Antibody
- Affiliations
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- 1Department of Neurology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea
- 2Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
- KMID: 2523958
- DOI: http://doi.org/10.46518/kjnmd.2021.13.2.64
Abstract
- Anti-3-hydroxy-3-methylglutaryl coenzyme A reductase (anti-HMGCR) antibody related immune-mediated necrotizing myopathy (IMNM) are usually associated with statin use. The disease has features of persistent muscle weakness and creatine kinase (CK) elevation after statin discontinuation. This report describes a 65-year-old female taking atorvastatin, presenting with both proximal lower extremity weakness. IMNM feature were detected on muscle biopsy and high anti-HMGCR autoantibody titer on enzyme-linked immunosorbent assay (ELISA). This patient was treated with corticosteroid. Muscle weakness and CK are improved after immunosuppressive therapy.
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