Korean J Med.  2012 Nov;83(5):641-646.

Primary Hyperparathyroidism with Ectopic Parathyroid Adenoma Detected by Both 99mTc-MIBI SPECT and Contrast-Enhanced Neck CT

• Lim HJ
• Shin DG
• Kim JB
• Kim JT
• Kim HJ
• Park MS
• Lee HJ

Abstract

An ectopic parathyroid gland is a major cause of persistent and recurrent hyperparathyroidism. Surgical success depends on accurate preoperative localization of the parathyroid adenoma. We herein report the case of a 52-year-old male patient who suffered from primary hyperparathyroidism for several years. He initially presented with urinary frequency, hypercalcemia, and a ureter stone. Ultrasonography and a 99mTc-sestamibi scan were performed, but failed to localize the parathyroid lesion. Four years later, the patient revisited our hospital, complaining of general weakness, headache, dyspepsia, and recurrent urinary symptoms secondary to persistent primary hyperparathyroidism. In addition, renal function was decreased and severe osteoporosis was found. We performed a 99mTc-sestamibi scan with single photon emission computed tomography (99mTc-MIBI SPECT) and contrast-enhanced neck CT, and detected an ectopic parathyroid adenoma in the upper anterior mediastinum. In conclusion, the combination of both 99mTc-MIBI SPECT and neck CT could permit better preoperative parathyroid localization, especially for mediastinal adenomas.

Keyword

Hyperparathyroidism, primary; Parathyroid neoplasms; Technetium Tc 99m-sestamibi; Tomography, emission-computed, single-photon

MeSH Terms

Adenoma
Dyspepsia
Headache
Humans
Hypercalcemia
Hyperparathyroidism
Hyperparathyroidism, Primary
Male
Mediastinum
Middle Aged
Neck
Osteoporosis
Parathyroid Glands
Parathyroid Neoplasms
Technetium Tc 99m Sestamibi
Tomography, Emission-Computed, Single-Photon
Ureter
Technetium Tc 99m Sestamibi