Korean J Nutr.  2008 Dec;41(8):733-741.

Plasma Levels of High Molecular Weight Adiponectin are Associated with Cardiometabolic Risks in Patients with Hypertension

• Chung HK
• Shin MJ

Abstract

In the present study, we comprehensively examined the associations of plasma levels of total adiponectin and high molecular weight (HMW) adiponectin with the features of cardiometabolic risks including body fat distribution, dyslipidemia, insulin resistance and inflammatory markers in a cross-sectional study of 110 treated hypertensive patients. Blood lipid profiles, high sensitivity C-reactive protein (hsCRP) and homeostasis model assessment of insulin resistance (HOMA-IR) derived from fasting glucose and insulin concentrations were determined. Plasma levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and intercellular adhesion molecule-1 (ICAM-1) were analyzed using ELISA. The results showed that plasma levels of HMW-adiponectin were negatively associated with body mass index (BMI, r = -0.203, p < 0.05) and waist circumference (r = -0.307, p < 0.01), which was not shown in total adiponectin. Plasma levels of HMW-adiponectin were negatively associated with triglyceride (r = -0.223, p < 0.05) and positively associated with HDL-cholesterol (r = 0.228, p < 0.05). Plasma levels of adiponectin were positively associated with HDL-cholesterol (r = 0.224, p < 0.05). Plasma levels of HMW-adiponectin were negatively associated with hsCRP (r = -0.276, p < 0.01) and IL-6 (r = -0.272, p < 0.01). In addition, there were weak associations between plasma levels of HMWadiponectin and TNF-alpha (r = -0.163, p = 0.07) and ICAM-1 (r = -0.158, p = 0.09). However, there were no significant associations of total adiponectin with inflammatory markers except hsCRP (r = -0.203, p < 0.05). Stepwise multiple linear regression analysis showed that only plasma levels of HMW-adiponectin was an independent factor influencing serum levels of hsCRP, a marker of systemic low grade inflammation, after adjusting for age, gender, BMI, waist circumference, alcohol intake, smoking status, blood lipids, total adiponectin and drug use (p < 0.01). These results suggest that HMW-adiponectin, rather than total adiponectin, is likely to be closely associated with the features of cardiometabolic risks in treated hypertensive patients and might be effective biomarker for the prediction of cardiovascular disease.

Keyword

high molecular weight adiponectin; cardiometabolic risk; hypertension; C-reactive protein; inflammation

MeSH Terms

Adiponectin
Body Fat Distribution
Body Mass Index
C-Reactive Protein
Cardiovascular Diseases
Cross-Sectional Studies
Dyslipidemias
Enzyme-Linked Immunosorbent Assay
Fasting
Glucose
Homeostasis
Humans
Hypertension
Inflammation
Insulin
Insulin Resistance
Intercellular Adhesion Molecule-1
Interleukin-6
Linear Models
Molecular Weight
Plasma
Smoke
Smoking
Tumor Necrosis Factor-alpha
Waist Circumference
Adiponectin
C-Reactive Protein
Glucose
Insulin
Intercellular Adhesion Molecule-1
Interleukin-6
Smoke
Tumor Necrosis Factor-alpha