J Korean Soc Pediatr Endocrinol.  2010 Apr;15(1):64-70.

Correlation of Clinical Characteristics and Levels of Adiponectin and Resistin in Human Cord Blood of Fetuses of Women with Gestational Diabetes and Pregnancy-induced Hypertension

• Kim EY
• Lee W
• Song CH
• Park SK

Abstract

PURPOSE
Adiponectin and resistin are potent regulators of glucose homeostasis and energy metabolism. In this study, we aimed to determine (1) the role of gestational diabetes (GDM) and pregnancy-induced hypertension (PIH) on the plasma levels of adiponectin and resistin in cord blood, and (2) the association of the hormones with anthropometric parameters at birth.
METHODS
This study investigated 80 pregnant women at 26-41 weeks of gestation, including 46 healthy pregnant woman as controls; 14 women with GDM; and 20 women with PIH, and 80 newborn infants (36 male, and 44 female). The following anthropometric measurements were obtained: maternal weight, length, body mass index (BMI), neonatal birth weight, neonatal length, and ponderal index. Cord blood samples were obtained from 80 neonates at the time of delivery. Plasma adiponectin levels (RIA) and resistin levels (ELISA) were measured.
RESULTS
Adiponectin levels were significantly lower in the fullterm group with GDM and fullterm group with PIH than the control group. Plasma resistin levels were significantly lower in the preterm and the fullterm groups with PIH than in the control group, and significantly higher in the fullterm group with GDM than in the PIH group. Similarly, adiponection was significantly lower in large for gestational age (LGA) infants than appropriate gestational age (AGA) and small for gestational age (SGA) infants, and resistin was significantly higher in LGA infants than in SGA infants. Adiponectin levels were negatively correlated with ponderal index, maternal HbA1c, and maternal body mass index (BMI). Plasma resistin levels were positively correlated with birth weight and maternal BMI.
CONCLUSION
Alteration of adiponectin and resistin levels in cord blood of fetuses of women with GDM and PIH may influence the development of metabolic disorders at all stages of development.

Keyword

Pregnancy complications; Adiponectin; Resistin

MeSH Terms

Adiponectin
Birth Weight
Body Mass Index
Diabetes, Gestational
Energy Metabolism
Female
Fetal Blood
Fetus
Gestational Age
Glucose
Homeostasis
Humans
Hypertension, Pregnancy-Induced
Infant
Infant, Newborn
Male
Parturition
Plasma
Pregnancy
Pregnancy Complications
Pregnant Women
Resistin
Adiponectin
Glucose
Resistin