Korean J Obstet Gynecol.  2011 Sep;54(9):485-491. 10.5468/KJOG.2011.54.9.485.

Concentration of cord serum adiponectin in normal and gestational diabetic pregnancies

• Cho AR
• Kim YJ
• Chun SH
• Cho SJ
• Park EA
• Park MH

• KMID: 2274072
• DOI: http://doi.org/10.5468/KJOG.2011.54.9.485

Abstract

OBJECTIVE
To investigate the effect of intrauterine environment on adiponectin level in cord blood through comparison of normal pregnancy group and gestational diabetes group.
METHODS
This cross sectional study included women with: normal pregnancy (n = 204); and patients with gestational diabetes mellitus (GDM) (n = 204). Among GDM patients, 118 were managed with diet alone and 86 were insulin requiring. Cord serum adiponectin concentration at birth was measured by enzyme-linked immunosorbent assay.
RESULTS
Cord serum adiponectin concentration was higher in GDM treatment pregnancies compared with normal pregnancies (P = 0.02). Cord serum adiponectin concentration was higher in female compared with male fetuses both normal and gestational diabetes pregnancies (P = 0.04, P = 0.03). In normal pregnancies, cord serum adiponectin concentration was positively correlated with gestational age (r = 0.2374, P < 0.02). In normal pregnancies, cord serum adiponectin concentration did not correlated with birth weight (r = -0.05, P > 0.05). Cord serum adiponectin concentration was not different between only diet treated women and insulin requiring women in GDM (P > 0.05).
CONCLUSION
Sex dimorphism for adiponectin and the change of adiponectin in GDM offsprings, first appear in utero. Higher adiponectin levels in females or GDM offsprings reflect increased adiposity of the fetuses.

Keyword

Cord serum adiponectin; Gestational diabetes mellitus; Sex characteristics; Adiposity

MeSH Terms

Adiponectin
Adiposity
Birth Weight
Diabetes, Gestational
Diet
Female
Fetal Blood
Fetus
Gestational Age
Humans
Insulin
Male
Parturition
Pregnancy
Sex Characteristics
Adiponectin
Insulin

Figure

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  Fig. 1 Correlation of gestational age to cord serum adiponectin in normal pregnancies.

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  Fig. 2 Correlation of birth weight to cord serum adiponectin in normal pregnancies. Adjusted for gestational age, infant's sex.

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  Fig. 3 Cord serum adiponectin concentration in normal pregnancies and gestational diabetes mellitus pregnancies. Adjusted for gestational age, infant's sex.

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