A Study of Estimation of Maturity of the Newborn Newborn Infant by Neurologic Examination and by Analysis of Creatinine in: Amniotic Fluid and Cord Blood

Moon, Song Soo

Abstract

Creatinine valuesin the amniotic fluid and cord blood were studied in 28 pregnancies. A scoring system ofr gestational age in the nursery room, based on 6 neurologic and 6 physical maturity, has been applied to that 28 newborn infants sampled. They were admitted to the Obstetric Ward and the Nursery Room of the Cho Sun University Hospital between May 1979 and August 1979. The following results were obstained: 1. Based on 2.0mg/100ml of creatinine concentration in amniotic fluid, fetal maturity was 27 cases(96.4%) of the total 28 cases. 2. The longer the gestational age, the greater the values of creatinine concentration in amniotic fluied in each group of patiens. Creatinine values in amniotic fluied were higher in those with abnormal pregnaneies than in those with normal pregnancies. For total pregnancies, the regression equation of creatinine concentration(y) against duration of gestation(x) was: y=-7.157+0.245x. The regression equation of creatinine concentration(y) against duration of neonatal assessment(x) was: y=1.442+0.034x. 3. The creatinine concentration in amniotic fluid was always higher than in the cord blood. The creatinine concentration in the cord blood were all normal values. 4. Total score was a good correlation with gestational age. The correlation coefficient for the total score against neonatal assessment(wks) was 0.79. The regression equation for total score(x) against neonatal assessment(y) was: y=23.55+0.389x. 5. In result, all maturity group was over 2.0mg/100ml of creatinine concentration in amniotic fluid, and correlation gestational age by L.M.P. and by neurologic assessment, the longer the gestational age, the greater the values of creatinine concentration in amniotic fluid. 6. This scoring system is more objective and reproductive than trying to guess gestational age on the presence or absence of individual signs.