Korean J Obstet Gynecol.  2002 Apr;45(4):659-665.

The clinical significance of Interleukin-6 mRNA expression in cervical intraepithelial neoplasia and cervical cancer

• Moon HS
• Choi EA
• Chung HW

Abstract

OBJECTIVES
Interleukin-6 is a pleiotrophic cytokine that is not only a mediator in major immunologic reactions but also a growth factor of keratinocytes. We studied IL-6 mRNA expression in cervical cancer, CIN and normal cervix. And we questioned whether its expression is related to cervical carcinogenesis and other prognostic factors.
METHODS
The normal cervical and cervical cancer tissues were taken from healthy women (n=16), and the patients with CIN (n=36) and cervical cancer (n=36). The IL-6 mRNA expression was examined by quantitative competitive PCR after polymerase chain reaction amplification of reverse transcriptase copies of RNA transcripts (RT-PCR).
RESULTS
There was no statistically different among cervical cancer, CIN and normal cervix (p>0.05). The IL-6 mRNA expression was not different according to the grades of CIN. Its expression was not correlated with the stage of cervical cancer, size of tumor, and histopathologic type (p>0.05).
CONCLUSION
These results suggested that IL-6 mRNA expression might not be associated with the cervical carcinogenesis and prognosis of cervical cancer.

Keyword

IL-6; Cervical cancer; CIN; Carcinogenesis

MeSH Terms

Carcinogenesis
Cervical Intraepithelial Neoplasia*
Cervix Uteri
Female
Humans
Interleukin-6*
Keratinocytes
Polymerase Chain Reaction
Prognosis
RNA
RNA, Messenger*
RNA-Directed DNA Polymerase
Uterine Cervical Neoplasms*
Interleukin-6
RNA
RNA, Messenger
RNA-Directed DNA Polymerase