Korean J Nosocomial Infect Control.  2013 Dec;18(2):44-50. 10.14192/kjnic.2013.18.2.44.

Trends in Antibiotic Use in a Single University Hospital

Affiliations
  • 1Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. molder@unitel.co.kr
  • 2Infection Control Service, Seoul National University Hospital, Seoul, Korea.
  • 3Department of Pharmacy, Seoul National University Hospital, Seoul, Korea.
  • 4Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea.

Abstract

BACKGROUND
The aim of this study was to evaluate antibiotic consumption by adult patients at a single university hospital in Korea between 2001 and 2012.
METHODS
We used the 2004 World Health Organization Anatomical Therapeutic Chemical Classification System definition of defined daily doses (DDD) per 1,000 patient-days to calculate the annual antibiotic consumption for 18 antibiotic groups. Chi-square linear-by-linear analysis was performed to evaluate antibiotic consumption trends for each group.
RESULTS
Average annual antibiotic consumption during 2001-2012 was 644.6 DDD/1,000 patient-days (standard deviation, 33.3 DDD/1,000 patient-days). Although no statistically significant change was observed during the study period, consumption of first- and second-generation cephalosporins, and aminoglycosides was significantly decreased, while that of beta-lactam/beta-lactamase inhibitors, fourth-generation cephalosporins, carbapenem, glycopeptide, linezolid, colistin, and quinolone increased significantly.
CONCLUSION
The total amount of prescribed antibiotics did not change, but the use of broad-spectrum antibiotics increased during the study period.

Keyword

Anti-bacterial agents; University hospitals; Utilization

MeSH Terms

Adult
Aminoglycosides
Anti-Bacterial Agents
Cephalosporins
Classification
Colistin
Hospitals, University
Humans
Korea
World Health Organization
Linezolid
Aminoglycosides
Anti-Bacterial Agents
Cephalosporins
Colistin

Figure

  • Fig. 1. The amount of annual oral, parenteral, and total antibiotic consumption between 2001 and 2012.

  • Fig. 2. (A) Change of annual consumption of antibiotics categorized into 18 groups. Antibiotics are plotted in (A) if mean defined daily dose/1,000 patient-days are above 30. (B) Change of annual consumption of antibiotics categorized into 18 groups. Antibiotics are plotted in (B) if mean defined daily dose/1,000 patient-days are below 30.

  • Fig. 3. (A) Change of annual consumption of broad spectrum antibiotics (3rd generation cephalosporin, 4th generation cephalosporin, carbapenem, glycopeptide, and quinolone) for patients in the intensive care units. (B) Change of antimicrobial resistance rate in the intensive care units. Carba, carbapenem; OXA, oxacillin; CTX, ceftriaxone; CIP, ciprofloxacin; VAN, vancomycin, ABA, A. baumannii; PAE, P. aeruginosa; SAU, S. aureus; ECO, E. coli; KPN, K. pneumoniae, EFM, E. faecium; %R, % resistant.


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Intervention for the Reduction of Long-term Carbapenem Prescriptions
Seong Jin Choi, Dong Eun Lee, Su Jeong Song, Hyein Kang, Chan Mi Lee, Chang Kyung Kang, Wan Bum Park, Nam Joong Kim, Eun Hwa Choi, Myoung-don Oh, Pyoeng Gyun Choe
Korean J Healthc Assoc Infect Control Prev. 2023;28(1):85-91.    doi: 10.14192/kjicp.2023.28.1.85.


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