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The Impact of Antibiotic Burden on the Selective Resistance of Gram Negative Bacteria in Children

Park S, Lee E, So HJ, Yoo RN, Lee J

Background: The purpose of this study was to investigate the association between antibiotic use and the antimicrobial resistance of gram-negative bacteria isolated from blood cultures in a pediatric population. Methods: From...
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Machine Learning for Antibiotic Resistance Prediction: A Prototype Using Off-the-Shelf Techniques and Entry-Level Data to Guide Empiric Antimicrobial Therapy

Feretzakis G, Sakagianni A, Loupelis E, Kalles D, Skarmoutsou N, Martsoukou M, Christopoulos C, Lada M, Petropoulou S, Velentza A, Michelidou S, Chatzikyriakou R, Dimitrellos E

Objectives: In the era of increasing antimicrobial resistance, the need for early identification and prompt treatment of multi-drug-resistant infections is crucial for achieving favorable outcomes in critically ill patients. As...
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Controlled releasing properties of gelatin nanofabric device containing chlorhexidine

Park DU, Um HS, Chang BS, Lee SY, Yoo KY, Choi WY, Lee JK

We aimed to evaluate the degradation and antimicrobial activity of novel chlorhexidine-containing gelatin nanofabric devices and their cytotoxicity in animals. The electro-spun device with a size of 3×4×0.4 mm 3...
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Current status of initial antibiotic therapy and analysis of infections in patients with solitary abdominal trauma: a multicenter trial in Korea

Lee GJ, Kyoung KH, Kim KH, Kim N, Sul YH, Lim KH, Hong SK, Cho H, Korean Society of Acute Care Surgery Clinical Research Group

Purpose: Proper use of antibiotics during emergency abdominal surgery is essential in reducing the incidence of surgical site infection. However, no studies have investigated the type of antibiotics and duration...
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Hypertriglyceridemia is a Risk Factor for Fever in Early Acute Non-biliary Pancreatitis

Lee SH, Park JM, Kim JH, Kim TS, Kang CD

Background/Aims: Fever is a common symptom of acute pancreatitis (AP). This study examined the factors associated with fever due to pancreatic inflammation in the early stages of non-biliary AP. Methods: This...
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Clindamycin Mono-Therapy of Hidradenitis Suppurativa Patients: A Single-Center Retrospective Study

An JH, Moon SJ, Shin JU, Kim DH, Yoon MS, Lee HJ

Background: A rifampicin (RF)-clindamycin (CL) combination therapy is recommended as the first-line treatment for moderate to severe hidradenitis suppurativa (HS). Although the long-term use of RF requires caution due to...
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Comparison of Infection Rates according to the Period of Prophylactic Antibiotic Use after Surgery in Patients with Distal Radius Fractures

Lee J, Lee Y, Jo YG, Kang SY, Bae KJ

Purpose: In general orthopedic surgery, the use of prophylactic antibiotics to prevent infection is recommended to be administered within 24 hours. However, there was no analysis on the incidence of...
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Clinical Characteristics of Spinal Epidural Abscess Accompanied by Bacteremia

Chae Hj, Kim J, Kim C

Objective : The treatment of choice for spinal epidural abscess (SEA) generally is urgent surgery in combination with intravenous antibiotic treatment. However, the optimal duration of antibiotic treatment has not...
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Performance of Modified-EUCAST Rapid Direct Antimicrobial Susceptibility Testing on Clinical Urine Samples

Mugiraneza J, Kwon M, Kim D, Lee SG, Lee H, Yong D

Background: The rapid antimicrobial susceptibility testing (AST) performed on urine samples would guide the adequate choice of antibiotics for obtaining better treatment outcomes in patients. Our study aimed to evaluate...
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Nicolau Syndrome after Intramuscular Aminoglycoside Injection

Kim JH, Kim JH, Kim SA, Baek SE, Oh DY

Nicolau syndrome is a rare iatrogenic adverse reaction caused by intramuscular injection of various medications. The clinical features include pain, erythematous swelling, infection, and local ischemic necrosis, but the pathogenesis...
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Subeschar culture using a punch instrument in unstageable wounds

Jung HB, Lee YJ

Background A patient’s overall condition sometimes does not allow for the complete removal of a dead eschar or injured slough in cases involving a pressure-injury skin lesion. This frequently occurs...
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Ten-year trends in antibiotic usage at a tertiary care hospital in Korea, 2004 to 2013

Kim B, Hwang H, Kim J, Lee Mj, Pai H

Background/Aims: This study was performed to evaluate trends in antibiotic usage at a tertiary care hospital in Korea. Methods: This study collated antibiotic prescription data and total patient days for inpatients...
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Drug induced liver injury: East versus West– a systematic review and meta-analysis

Low EXS, Zheng Q, Chan E, Lim SG

Drug induced liver injury (DILI) may be different in the East compared to the West due to differing disease prevalence, prescribing patterns and pharmacogenetic profiles. To review existing literature on...
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Clinical Features of and Antibiotic Resistance in Recurrent Urinary Tract Infection in Children with Vesicoureteral Reflux

Eun SH, Kang JM, Kim JH, Kim SW, Lee YS, Han SW, Ahn JG

Purpose: This study aimed to investigate the clinical features of recurrent urinary tract infection (UTI) in children with vesicoureteral reflux (VUR) and to compare the causative uropathogen and antibiotic susceptibility...
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The Role of Wound Swab Microbial Cultures and Antibiotic Sensitivity Results in the Management of Sacrococcygeal Pilonidal Abscess

Cheng C, Lai JM, Mori K

Purpose: Current practice for patients who present to hospitals with acute sacrococcygeal pilonidal abscess is operative management. Wound swabs are routinely taken peri-operatively and antibiotics are initiated empirically pending culture...
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The role of antibiotic prophylaxis in mild to moderate isolated hydronephrosis detected in antenatal screening

Rianthavorn P, Phithaklimnuwong S

PURPOSE: To determine whether continuous antibiotic prophylaxis (CAP) could prevent urinary tract infection (UTI) in mild to moderate antenatal isolated hydronephrosis (IH), characterized by hydronephrosis without ureter and bladder abnormalities,...
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Prescription of antibiotics after tooth extraction in adults: a nationwide study in Korea

Choi YY

OBJECTIVES: This study aimed to understand the nationwide patterns of antibiotic prescription after tooth extraction in adult patients. MATERIALS AND METHODS: This study analyzed dental records from the National Health Insurance...
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First-line Helicobacter pylori Eradication Rate of the 10-day Hybrid Therapy

Park JH, Kim D, Choe JW, Kim SY, Jung SW, Hyun JJ, Jung YK, Koo JS, Yim HJ, Lee SW

Background/Aims: To improve the eradication rate of a first-line therapy for Helicobacter pylori infection, alternate regimens such as sequential, concomitant, and hybrid therapies have been tried. The aim of this...
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Role of Intestinal Microbiota in Metabolism of Voglibose In Vitro and In Vivo

Nepal MR, Kang MJ, Kim GH, Cha DH, Kim JH, Jeong TC

Background Voglibose, an α-glucosidase inhibitor, inhibits breakdown of complex carbohydrates into simple sugar units in intestine. Studies showed that voglibose metabolism in the liver might be negligible due to its poor...
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Association between Full Electronic Medical Record System Adoption and Drug Use: Antibiotics and Polypharmacy

Park YT, Kim D, Park RW, Atalag K, Kwon IH, Yoon D, Choi M

OBJECTIVES: We investigated associations between full Electronic Medical Record (EMR) system adoption and drug use in healthcare organizations (HCOs) to explore whether EMR system features such as electronic prescribing, medicines...
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