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Determination of Colistin Resistance by Simple Disk Diffusion Test Using Modified Mueller-Hinton Agar

Uwizeyimana JD, Kim D, Lee H, Byun JH, Yong D

BACKGROUND: Colistin has become a last-resort antibiotic for the management of multidrug-resistant gram-negative bacteria. The disk diffusion test is cheap and easy to perform but may be unreliable for colistin...
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Evaluation of Synergistic Effect of Combined Treatment with Linalool and Colistin on Multidrug-Resistant Acinetobacter baumannii to Expand Candidate for Therapeutic Option

Kim UJ, Kim CM, Jang SJ, Lee SB, Cho SS, Jeong SH, Ko YJ, Kang SH, Park G, Kim DM, Yoon NR, Ahn YJ, Lim DH, Kook JK

BACKGROUND: Acinetobacter baumannii infection is a significant health problem worldwide due to increased drug resistance. The limited antimicrobial alternatives for the treatment of severe infections by multidrug-resistant A. baumannii (MDRAB)...
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Intravenous Colistin Therapy for Multidrug-Resistant Gram-Negative Bacterial Infections in Major Burn Injuries

Cho GY, Yoon J, Chun JW, Kim Y, Yim H, Kym D, Hur J, Chun W, Cho YS

PURPOSE: The aim of this study was to investigate the characteristics of Acute Kidney Injury Network (AKIN)-defined nephrotoxicity in patients undergoing intravenous colistimethate sodium (CMS) therapy for major burns. METHODS: This...
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Prevalence and Risk Factors of Carbapenem-resistant Enterobacteriaceae Acquisition in an Emergency Intensive Care Unit in a Tertiary Hospital in Korea: a Case-Control Study

Kang JS, Yi J, Ko MK, Lee SO, Lee JE, Kim KH

BACKGROUND: Infections caused by carbapenem-resistant Enterobacteriaceae (CRE) are associated with high mortality rates and their treatment is difficult because treatment is limited to certain antibiotics, such as colistin and tigecycline....
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MCR1 and KPC2 Co-producing Klebsiella pneumoniae Bacteremia: First Case in Korea

Park JY, Heo ST, Kwon KT, Song DY, Lee KJ, Choi JA

Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-KP) has been disseminating nationwide due to clonal spread and is taking a serious action at the national level in Korea. The mobilized colistin resistance...
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Colistin, Hot Potato for the Therapy of Carbapenem-resistant Acinetobacter baumannii infections

Park SW

No abstract available.
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Early Intravenous Colistin Therapy as a Favorable Prognostic Factor for 28-day Mortality in Patients with CRAB Bacteremia: a Multicenter Propensity Score-Matching Analysis

Kim T, Park KH, Yu SN, Park SY, Park SY, Lee YM, Jeon MH, Choo EJ, Kim TH, Lee MS, Lee E

BACKGROUND: Carbapenem-resistant Acinetobacter baumannii (CRAB) infection is associated with high mortality. One of the strategies to reduce the mortality in patients with CRAB infections is to use intravenous colistin early...
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Carbapenem-resistant Enterobacteriaceae: recent updates and treatment strategies

Lee HJ, Lee DG

The emergence of carbapenem-resistant Enterobacteriaceae (CRE) has become a major problem within the field of healthcare-associated infections worldwide in the last decade. The treatment of infections caused by CRE is...
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Intensive Care Unit Relocation and Its Effect on Multidrug-Resistant Respiratory Microorganisms

Kim HJ, Jeong E, Choe PG, Lee SM, Lee J

BACKGROUND: Infection by multidrug-resistant (MDR) pathogens leads to poor patient outcomes in intensive care units (ICUs). Contact precautions are necessary to reduce the transmission of MDR pathogens. However, the importance...
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Detection of mcr-1 Plasmids in Enterobacteriaceae Isolates From Human Specimens: Comparison With Those in Escherichia coli Isolates From Livestock in Korea

Yoon EJ, Hong JS, Yang JW, Lee KJ, Lee H, Jeong SH

BACKGROUND: The emerging mobile colistin resistance gene, mcr-1, is an ongoing worldwide concern and an evaluation of clinical isolates harboring this gene is required in Korea. We investigated mcr-1-possessing Enterobacteriaceae...
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Differences in Colistin-resistant Acinetobacter baumannii Clinical Isolates Between Patients With and Without Prior Colistin Treatment

Park YJ, Hong DJ, Yoon EJ, Kim D, Choi MH, Hong JS, Lee H, Yong D, Jeong SH

BACKGROUND: The increasing morbidity and mortality rates associated with Acinetobacter baumannii are due to the emergence of drug resistance and the limited treatment options. We compared characteristics of colistin-resistant Acinetobacter...
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Antimicrobial Therapy for Infections Caused by Carbapenem-Resistant Gram-Negative Bacteria

Wi YM, Kang CI

Carbapenem-resistance emerging in Gram-negative pathogens, such as Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii, has become a major human health problem globally. The therapeutic options available for carbapenem-resistant pathogens are...
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Extensively Drug-Resistant Escherichia coli Sequence Type 1642 Carrying an IncX3 Plasmid Containing the blaKPC-2 Gene Associated with Transposon Tn4401a

Jeong S, Kim JO, Yoon EJ, Bae IK, Lee W, Lee H, Park Y, Lee K, Jeong SH

BACKGROUND: Extensively drug-resistant (XDR) Enterobacteriaceae carrying the bla(KPC) gene have emerged as a major global therapeutic concern. The purpose of this study was to analyze the complete sequences of plasmids...
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Antimicrobial resistance of Stx2e positive Escherichia coli before and after ban on antibiotic growth promoters

Do KH, Byun JW, Lee WK

The emergence of antimicrobial resistant Escherichia (E.) coli is a major problem in pig farms. To tackle this issue, in July 2011, the Korean government banned the use of antimicrobials...
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Colistin Resistance in Escherichia coli Isolates From Patients With Bloodstream Infection in Korea

Kim YA, Yong D, Jeong SH, Lee K

No abstract available.
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Successful Treatment of Acinetobacter Baumannii Meningitis with Colistin

Choi PK, Kim KH, Kang HG

Acinetobacter baumannii is a source of opportunistic infection in hospital and can cause central nervous system infection mainly by neurosurgical operation. Community acquired infection by Acinetobacter baumannii is very rare....
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A 5-year Surveillance Study on Antimicrobial Resistance of Acinetobacter baumannii Clinical Isolates from a Tertiary Greek Hospital

Maraki S, Mantadakis E, Mavromanolaki VE, Kofteridis DP, Samonis G

BACKGROUND: Acinetobacter baumannii has emerged as a major cause of nosocomial outbreaks. It is particularly associated with nosocomial pneumonia and bloodstream infections in immunocompromised and debilitated patients with serious underlying...
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Clinical Effectiveness and Nephrotoxicity of Aerosolized Colistin Treatment in Multidrug-Resistant Gram-Negative Pneumonia

Park SY, Park MS, Chung CR, Kim JS, Park SJ, Lee HB

BACKGROUND: Colistin (polymyxin E) is active against multidrug-resistant Gram-negative bacteria (MDR-GNB). However, the effectiveness of inhaled colistin is unclear. This study was designed to assess the effectiveness and safety of...
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A Case of Successful Treatment Using Topical Colistin in Multidrug-resistant Pseudomonas aeruginosa Bacterial Ulcer

Seo MH, Na YH, Lee DH, Kim JH

PURPOSE: To report a successful case of corneal ulcer caused by multidrug-resistant Pseudomonas aeruginosa using topical colistin in an immobilized patient who was hospitalized for a long period. CASE SUMMARY: An...
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In Vitro Interactions of Antibiotic Combinations of Colistin, Tigecycline, and Doripenem Against Extensively Drug-Resistant and Multidrug-Resistant Acinetobacter baumannii

Park GC, Choi JA, Jang SJ, Jeong SH, Kim CM, Choi IS, Kang SH, Park G, Moon DS

BACKGROUND: Acinetobacter baumannii infections are difficult to treat owing to the emergence of various antibiotic resistant isolates. Because treatment options are limited for multidrug-resistant (MDR) A. baumannii infection, the discovery...
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