Tuberc Respir Dis.  2008 Feb;64(2):102-108.

A Trial of Aerosolized Colistin for the Treatment of Nosocomial Pneumonia due to Multidrug-resistant Acinetobacter baumannii

• Kim C
• Kim DG
• Kang HR
• Choi JH
• Lee CY
• Hwang YI
• Shin TR
• Park SM
• Park YB
• Lee JY
• Jang SH
• Kim CH
• Mo EK
• Lee MG
• Hyun IG
• Jung KS
• Choi YJ
• Lee JW

Abstract

BACKGROUND: Recently, multidrug-resistant (MDR) A. baumannii has been implicated for a significant proportion of nosocominal pneumonia in many intensive care units (ICUs), and its acquisition may increase mortality and the length of stay in the ICU. Aerosolized colistin has been successfully used in patients with cystic fibrosis, but there is a lack of data regarding the use of aerosolized colistin in patients with nosocomial pneumonia.
METHODS
We conducted the present study to assess the effectiveness of aerosolized colistin for the treatment of MDR A. baumannii nosocomial pneumonia. We retrospectively reviewed the medical records of 10 patients who had been hospitalized in the medical ICU and had received aerosolized colistin as a therapy for MDR A. baumannii pneumonia.
RESULTS
The mean duration of aerosolized colistin therapy was 12.7+/-2.4 days. Nine (90%) of 10 patients showed a favorable response to the therapy. Follow-up cultures were available for all patients, and the responsible pathogen was completely eradicated. One patient suffered from bronchospasm, which resolved after treatment with nebulized salbutamol.
CONCLUSION
Our results corroborate previous reports that aerosolized colistin may be an effective and safe choice for the treatment of nosocomial pneumonia caused by MDR A. baumannii. Larger prospective controlled clinical studies are warranted to validate further the effectiveness and safety of aerosolized colistin therapy.

Keyword

Acinetobacter baumannii; Aerosolized colistin; Nosocomial pneumonia

MeSH Terms

Acinetobacter
Acinetobacter baumannii
Albuterol
Bronchial Spasm
Colistin
Cystic Fibrosis
Follow-Up Studies
Humans
Intensive Care Units
Length of Stay
Medical Records
Pneumonia
Retrospective Studies
Albuterol
Colistin

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