J Bacteriol Virol.  2015 Mar;45(1):51-53. 10.4167/jbv.2015.45.1.51.

ISAba15 Inserted into Outer Membrane Protein Gene carO in Acinetobacter baumannii

Affiliations
  • 1Department of Molecular Cell Biology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Korea. ksko@skku.edu

Abstract

We identified ISAba15 inserted into the carO gene in an Acinetobacter baumannii isolate. The insert disrupted the lpxD gene, resulting in colistin resistance in A. baumannii. Persistence in carbapenem resistance in A. baumannii isolates with an intact carO gene indicates that loss of the encoded CarO may play a minor role in carbapenem resistance.

Keyword

Carbapenem; Insertion sequence (IS); Antimicrobial resistance

MeSH Terms

Acinetobacter baumannii*
Colistin
Drug Resistance, Bacterial
Membrane Proteins*
Colistin
Membrane Proteins
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