Korean J Nephrol.  2001 Jan;20(1):147-153.

Two Cases of Combined Liver-kidney Transplantation in Patients with End Stage Renal Diseases Associated with Hepatitis B Related Liver Cirrhosis

• Kim YM
• Lee YJ
• Lee JS
• Chang SP
• Park JH
• Kim EK
• Jung SH
• Lee YS
• Park SK
• Han DJ
• Lee SG

Abstract

We here report two cases of combined liver-kidney transplantation in patients with both end stage renal disease and hepatitis B related liver cirrhosis. The first case was a 55-year-old man with hepatitis B related liver cirrhosis and chronic renal failure, who received cadaveric liver and kidney transplantation. Immunosuppressants were cyclosporine, prednisolone, and mycophenolate mofetil. Clinical course was uneventful except for hemolytic anemia due to alloimmunization that occurs after ABO-mismatched solid organ transplantation. Hemoglobin level became stable after plasmapheresis. His renal and hepatic function is maintained up to the present time. The second case was a 42-year-old man with nephrotic syndrome and liver cirrhosis. The patient underwent living related-combined liver-kidney transplantation. Donors were his son and brother. Blood type of the patient and donors were identical and the result of HLA crossmatch was negative. On the 14th postoperative day, stenosis at anastomotic site of hepatic artery was detected. After balloon angioplasty hepatic function was normalized. At 8 months after the transplantation, the patient is stable without adverse events.

Keyword

Combined liver-kidney transplantation; Liver cirrhosis; Chronic renal failure

MeSH Terms

Adult
Anemia, Hemolytic
Angioplasty, Balloon
Cadaver
Constriction, Pathologic
Cyclosporine
Hepatic Artery
Hepatitis B*
Hepatitis*
Humans
Immunosuppressive Agents
Kidney Failure, Chronic
Kidney Transplantation
Liver Cirrhosis*
Liver*
Middle Aged
Nephrotic Syndrome
Organ Transplantation
Plasmapheresis
Prednisolone
Siblings
Tissue Donors
Transplants
Cyclosporine
Immunosuppressive Agents
Prednisolone