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Association between History of Pregnancy and Liver Fibrosis Using Fibrosis-4 Index in Korean Postmenopausal Women: A Nationwide Population-Based Study

Ahn JJ, Park JH, Kim DH, Kim HJ, Ko HS, Kwon JY, Koh YS, Jung JH, Lee GN, Han K

Background: The association between a history of pregnancy and liver fibrosis remains unclear. Herein, we investigated the association between reproductive factors, including a history of pregnancy and liver fibrosis, in...
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Impacts of muscle mass dynamics on prognosis of outpatients with cirrhosis

Kim TH, Jung YK, Yim HJ, Baik JW, Yim SY, Lee YS, Seo YS, Kim JH, Yeon JE, Byun KS

Background/Aims: Sarcopenia negatively affects the prognosis of cirrhotic patients, but clinical implications of changes in muscle mass remain unclear. We aimed to elucidate its role in the prognosis of outpatients...
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Impact of nationwide hepatocellular carcinoma surveillance on the prognosis in patients with chronic liver disease

Sohn W, Kang D, Kang M, Guallar E, Cho J, Paik YH

Background/Aims: This study aimed to investigate the effect of hepatocellular carcinoma (HCC) surveillance using the Korea National Liver Cancer Screening Program on the receipt of curative treatment for HCC and...
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Usefulness of 2D shear wave elastography for the evaluation of hepatic fibrosis and treatment response in patients with autoimmune hepatitis

Soh EG, Lee YH, Kim YR, Yoon KH, Choi KH

Purpose: The purpose of this study was to determine the usefulness of two-dimensional shear wave elastography (2D SWE) in the assessment of liver stiffness (LS) and dispersion slope (DS) to...
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The Effects of Irisin on the Interaction between Hepatic Stellate Cell and Macrophage in Liver Fibrosis

Do DV, Park SY, Nguyen GT, Choi DH, Cho EH

Background: Hepatic stellate cells (HSCs) are the central players interacting with multiple cell types in liver fibrosis. The crosstalk between HSCs and macrophages has recently become clearer. Irisin, an exercise-responsive...
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Improved anti-fibrotic effects by combined treatments of simvastatin and NS-398 in experimental liver fibrosis models

Kang SH, Yim HJ, Hwang Jw, Kim Mj, Lee YS, Jung YK, Yim H, Kim BH, Park HC, Seo YS, Kim JH, Yeon JE, Um SH, Byun KS

Background/Aims: Efficient anti-fibrotic therapies are required for the treatment of liver cirrhosis. Hydroxymethylglutaryl-coenzyme A reductase inhibitors (statins) and cyclooxygenase-2 (COX-2) inhibitors have been reported to have anti-fibrotic effects. Here, we...
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Effect of moderate-to-severe hepatic steatosis on neutralising antibody response among BNT162b2 and CoronaVac recipients

Cheung KS, Lam LK, Hui RWH, Mao X, Zhang RR, Chan KH, Hung IF, Seto WK, Yuen MF

Background/Aims: Studies of hepatic steatosis (HS) effect on COVID-19 vaccine immunogenicity are lacking. We aimed to compare immunogenicity of BNT162b2 and CoronaVac among moderate/severe HS and control subjects. Methods: Two hundred...
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Effect of L-carnitine on quality of life in covert hepatic encephalopathy: a randomized, double-blind, placebo-controlled study

Yoon EL, Ahn SB, Jun DW, Cho YK, Song DS, Jeong JY, Kim HY, Jung YK, Song MJ, Kim SE, Kim HS, Jeong SW, Kim SG, Lee TH

Background/Aims: L-carnitine is potentially beneficial in patients with hepatic encephalopathy (HE). We aimed to evaluate the impact of L-carnitine on the quality of life and liver function in patients with...
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Reappraisal of sepsis-3 and CLIF-SOFA as predictors of mortality in patients with cirrhosis and infection presenting to the emergency department: A multicenter study

Kim JH, Jun BG, Lee M, Lee HA, Kim TS, Heo JW, Moon DH, Kang SH, Suk KT, Kim MY, Kim YD, Cheon GJ, Baik SK, Kim DJ, Choi DH

Background/Aims: Sepsis-3 criteria and quick Sequential Organ Failure Assessment (qSOFA) have been advocated to be used in defining sepsis in the general population. We aimed to compare the Sepsis-3 criteria...
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Primary hepatic sarcoidosis presenting with cholestatic liver disease and mimicking primary biliary cholangitis: a case report

Park YJ, Woo HY, Kim MB, Ahn J, Heo J

Sarcoidosis often involves the liver. However, primary hepatic sarcoidosis confined to the liver without evidence of systemic involvement is rare. We report the case of a 37-year-old man with hepatic...
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Liver Cirrhosis and Sarcopenia

Chon HY, Lee TH

Malnutrition is one of the most common complications in patients with liver cirrhosis. In previous studies, cirrhotic patients with severe malnutrition have been associated with higher morbidity and mortality rates...
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Outcomes of endoscopic submucosal dissection for superficial esophageal neoplasms in patients with liver cirrhosis

Choi YK, Noh JH, Kim DH, Na HK, Ahn JY, Lee JH, Jung KW, Choi KD, Song HJ, Lee GH, Jung HY

Background/Aims: The treatment of superficial esophageal neoplasms (SENs) in cirrhotic patients is challenging and rarely investigated. We evaluated the outcomes of endoscopic submucosal dissection (ESD) to determine the efficacy and...
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Safety of direct oral anticoagulants compared to warfarin in cirrhotic patients with atrial fibrillation

Yoo SY, Kim E, Nam GB, Lee D, Shim JH, Kim KM, Lim YS, Lee HC, Chung YH, Lee YS, Choi J

Background/Aims: The safety of direct oral anticoagulants (DOACs) compared with warfarin in patients with both nonvalvular atrial fibrillation (AF) and clinically confirmed liver cirrhosis (LC) has not been well studied....
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Acute on chronic liver failure in cirrhosis

Tonon M, Piano S

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Comparison of superb microvascular imaging and shear wave elastography for assessing liver fibrosis in chronic hepatitis B

Tosun M, Uslu H

Purpose: The present study investigated the effectiveness and applicability of superb microvascular imaging (SMI) in determining the degree of liver fibrosis noninvasively in comparison with shear wave elastography (SWE). Methods: Ninety-eight...
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The role of transjugular intrahepatic portosystemic shunt in patients with portal hypertension: Advantages and pitfalls

Lee HL, Lee SW

Transjugular intrahepatic portosystemic shunt (TIPS) is an effective interventional procedure to relieve portal hypertension, which is a main mechanism for the development of complications of liver cirrhosis (LC), such as...
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Leaky gut-derived tumor necrosis factor-α causes sarcopenia in patients with liver cirrhosis

Kawaguchi T, Torimura T

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Association between serum tumor necrosis factor-α and sarcopenia in liver cirrhosis

Han JW, Kim DI, Nam HC, Chang UI, Yang JM, Song DS

Background/Aims: Sarcopenia is an independent prognostic factor of liver cirrhosis (LC). However, the association between LC-related systemic inflammation and sarcopenia is unclear. Methods: Sprague-Dawley rats were treated with thioacetamide (TAA) or...
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Living donor liver transplantation in an infant patient with progressive familial intrahepatic cholestasis along with hepatocellular carcinoma: a case report

Namgoong JM, Hwang S, Kim DY, Ahn CS, Kwon H, Ha S, Kim KM, Oh SH

Progressive familial intrahepatic cholestasis (PFIC) is an autosomal recessive inherited disease requiring liver transplantation (LT). Hepatocellular carcinoma (HCC) is very rare in infants. We present a case of living donor...
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Multiple Spider Angiomas as a Predictive Diagnostic Marker of Alcoholic Liver Cirrhosis

Hong JK, Han HS, Shin SH, Koh YG, Li K, Kim BJ, Yoo KH

  • KMID: 2527681
  • Korean J Dermatol.
  • 2022 Mar;60(3):178-181.
Spider angioma (SA) may present as solitary or multiple lesions. Studies have shown that approximately 60% of pregnant women and 38% of healthy children have at least one spider telangiectasia....
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