Korean J Hepatol.  2009 Sep;15(3):362-369. 10.3350/kjhep.2009.15.3.362.

Four patients with hepatitis A presenting with fulminant hepatitis and acute renal failure and who underwent liver transplantation

• Oh SH
• Lee JH
• Hwang JW
• Kim HY
• Lee CH
• Gwak GY
• Choi MS
• Koh KC
• Paik SW
• Yoo BC

• KMID: 1374965
• DOI: http://doi.org/10.3350/kjhep.2009.15.3.362

Abstract

Hepatitis A is generally known as a mild, self-limiting disease of the liver, but in rare instances it can progress to fulminant hepatitis, which may require liver transplantation for recovery. Such cases are known to be related to old age and underlying liver disease. We report four cases of hepatitis A in which patients presented with fulminant hepatitis and acute renal failure and underwent liver transplantation. The following common features were observed in our cases: (1) occurrence in relatively old age (> or =39 years old), (2) association with acute renal failure, (3) presence of hepatomegaly, and (4) microscopic features of submassive hepatic necrosis.

Keyword

Hepatitis A; Fulminant hepatitis; Acute renal failure; Liver transplantation

MeSH Terms

Adult
Age Factors
Female
Hepatitis/complications/*diagnosis/therapy
Hepatitis A/complications/*diagnosis
Hepatomegaly/diagnosis/etiology
Humans
Kidney Failure, Acute/complications/*diagnosis
Liver/pathology
Liver Cirrhosis/diagnosis/etiology
*Liver Transplantation
Male
Tomography, X-Ray Computed