Korean J Biol Psychiatry.  2016 Feb;23(1):1-11. 10.0000/kjbp.2016.23.1.1.

Novel Pharmacological Treatment for Depression

• Jeong HJ
• Moon E

• KMID: 2251105
• DOI: http://doi.org/10.0000/kjbp.2016.23.1.1

Abstract

Development of various antidepressants such as monoamine oxidase inhibitors, tricyclic antidepressants, selective serotonin reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, and noradrenergic and specific serotonergic antidepressant has led to a tremendous progression of pharmaceutical treatment for depression, but still there are some limitations of current antidepressants, such as treatment-resistant depression and delayed onset of antidepressants. The pathogenesis of depression is unclear because depression is a heterogeneous disease state, and the mechanisms of antidepressants remain uncertain as well. Nevertheless, in an attempt to develop novel antidepressants, some trials have been conducted based on the potential biological mechanism discovered in the numerous research results. This review will provide information about the potential novel antidepressants and the current states of clinical studies using them. In particular, some potential novel antidepressants anti-inflammatory agents, antioxidants, anticholinergics, modulators of Hypothalamic Pituitary Adrenal Axis, glutamate, and opioid systems, as well as some neuropeptides such as susbstance P, neuropeptide Y, and galanin will be discussed.

Keyword

Depressive disorder; Treatment-resistant depression; Novel antidepressant; Pharmacotherapy

MeSH Terms

Anti-Inflammatory Agents
Antidepressive Agents
Antidepressive Agents, Tricyclic
Antioxidants
Axis, Cervical Vertebra
Cholinergic Antagonists
Depression*
Depressive Disorder
Drug Therapy
Galanin
Glutamic Acid
Monoamine Oxidase Inhibitors
Neuropeptide Y
Neuropeptides
Norepinephrine
Serotonin
Serotonin Uptake Inhibitors
Anti-Inflammatory Agents
Antidepressive Agents
Antidepressive Agents, Tricyclic
Antioxidants
Cholinergic Antagonists
Galanin
Glutamic Acid
Monoamine Oxidase Inhibitors
Neuropeptide Y
Neuropeptides
Norepinephrine
Serotonin
Serotonin Uptake Inhibitors