Korean J Biol Psychiatry.
2015 Nov;22(4):149-154. 10.0000/kjbp.2015.22.4.149.
Other N-Methyl-D-Aspartate (NMDA) Receptor Antagonists with a Rapid Onset of Action and Less Side Effect in the Treatment of Depression
- Affiliations
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- 1Department of Psychiatry, Dankook University Cheonan Hospital, Dankook University College of Medicine, Cheonan, Korea.
- 2Department of Psychiatry, Soonchunhyang Hospital Cheonan, Soonchunhyang University College of Medicine, Cheonan, Korea. leehway@gmail.com
- KMID: 2251056
- DOI: http://doi.org/10.0000/kjbp.2015.22.4.149
Abstract
- Mood disorder is a common psychiatric illness with a high lifetime prevalence in the general population. Many prescribed antidepressants modulate monoamine neurotransmitters including serotonin, norepinephrine and dopamine. There has been greater focus on the major excitatory neurotransmitter in the human brain, glutamate, in the pathophysiology and treatment of major depressive disorder (MDD). Recently, ketamine, an N-methyl-D-aspartate receptor antagonist, has received attention and has been investigated for clinical trials and neurobiological studies. In this article, we will review the clinical evidence for glutamatergic dysfunction in MDD, the progress with ketamine as a rapidly acting antidepressant, and other N-methyl-D-aspartate receptor antagonist for treatment-resistant depression.
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