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Impaired Cholesterol Metabolism, Neurons, and Neuropsychiatric Disorders

Cheon SY

Cholesterol metabolism plays an essential role in cellular functions (including as a component of the plasma membrane, as an energy source, and in hormone production) under normal conditions. Dysregulated cholesterol...
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Childhood Sexual Abuse and Cortical Thinning in Adults With Major Depressive Disorder

Kim J, Lee C, Kang Y, Kang W, Kim A, Tae WS, Ham BJ, Chang J, Han KM

Objective A growing body of evidence reports on the effect of different types of childhood abuse on the structural and functional architecture of the brain. In the present study, we...
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Brain-derived Neurotrophic Factor and High Sensitive C-reactive Protein in Bipolar Depression and Unipolar Depression: The Practical Usage as a Discriminatory Tool

Shahyad S, Kheirabadi GR, Jahromi GP, Massaly M

Objective: Brain-derived neurotrophic factor (BDNF) and high sensitive C-reactive protein (hs-CRP) have been reported to play roles in depression and bipolar disorder (BD). However, the probable discriminatory properties of these...
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Hydroxychloroquine, Interleukin-6 Receptor Antagonists and Corticoid Treatments of Acute COVID-19 Infection: Psychiatric Symptoms and Mental Disorders 4 Months Later

Gasnier M, Choucha W, Montani D, Noël N, Verstuyft C, Radiguer F, Monnet X, Becquemont L, Corruble E, Colle R, on behalf of the COMEBAC Study Group

Objective: Psychiatric symptoms and mental disorders are common after Coronavirus Disease-19 (COVID-19). Some drugs used to treat acute COVID-19 have psychiatric side effects. We assessed the psychiatric symptoms and mental...
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Botulinum Toxin in Facial Aesthetics Affects the Emotion Process: A Meta-analysis of Randomized Controlled Trials

Costa ACdF, Silva ECd, Gondim DV

This study aimed to conduct a meta-analysis of randomized controlled trials (RCTs) to evaluate the effects of the btulinum toxin-A (BT-A) in patiets with mood disorders. PubMed, Scopus, Web of...
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Clinical Utility of Fluid Biomarker in Depressive Disorder

Serretti A

Major depressive disorders are ranked as the single largest contributor to non-fatal health loss and biomarkers could largely improve our routine clinical activity by predicting disease course and guiding treatment....
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The Difference of Cognitive Function in Posttraumatic Stress Disorder and Major Depressive Disorder According to Severity of Symptom

Park C, Gim MS

Objectives This study compared cognitive functions according to the detailed symptoms and severity of posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) and evaluated the relationship between the characteristics...
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Reduced Sulcal Depth in Central Sulcus of Major Depressive Disorder

Shin SJ, Kim A, Han KM, Tae WS, Ham BJ

  • KMID: 2535066
  • Exp Neurobiol.
  • 2022 Oct;31(5):353-360.
  • doi: 10.5607/en22031
Major depressive disorder (MDD) is one of the most common psychiatric disorders, and present various symptoms such as the dysregulation of mood, cognition, and behavior. The purpose of the present...
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Clinical Factors Related to Change of Depression Severity in Major Depressive Disorder Through Index Electroconvulsive Therapy

Yang JW, Kim YT, Kim HC, Jung SW, Lee H

  • KMID: 2534714
  • J Korean Soc Biol Ther Psychiatry.
  • 2022 Oct;28(3):98-108.
Objectives:The aim of this study was to investigate the factors associated with changes in depression severity in index electroconvulsive therapy (ECT) for major depressive disorder. Methods:A retrospective analysis was performed on...
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Association Between the C4 Binding Protein Level and White Matter Integrity in Major Depressive Disorder

Park J, Kang Y, Han KM, Tae WS, Kang UB, Chu H, Ham BJ

Objective Considerable evidence suggests that neuroinflammation plays an important role in the pathophysiology of major depressive disorder (MDD). However, the relationship between serum C4 binding protein (C4BP) and white matter...
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Safety and Effectiveness of Desvenlafaxine in Korean Patients with Major Depressive Disorder: A 6-month Postmarketing Surveillance Study

Roh S, Lee KS, Choi S, Kim JM

Objective: Although the safety and efficacy of desvenlafaxine have been demonstrated, long-term evidence in Asians is lacking. We examined the safety and effectiveness of desvenlafaxine for up to 6 months...
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Abnormal Dynamic Functional Connectivity of the Left Rostral Hippocampus in Predicting Antidepressant Efficacy in Major Depressive Disorder

Xue SW, Kuai C, Xiao Y, Zhao L, Lan Z

Objective Some pharmacological treatments are ineffective in parts of patients with major depressive disorder (MDD), hence this needs prediction of effective treatment responses. The study aims to examine the relationship...
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Trends of Internet Search Volumes for Major Depressive Disorder Symptoms During the COVID-19 Pandemic in Korea: An Interrupted Time-Series Analysis

Background: The effect of coronavirus disease 2019 (COVID-19) pandemic on public mental health has been increasing. Additionally, the underlying psychological stressors remain unexplored, and few studies have been conducted nationally...
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Korean Medication Algorithm Project for Depressive Disorder 2021 (VI): Non-Pharmacological Biological Treatments

Jeong JH, Woo YS, Bahk WM, Wang SM, Seo JS, Park YM, Kim W, Shim SH, Lee JG, Jang SH, Yang CM, Jung MH, Sung HM, Choo IH, Yoon BH, Lee SY, Jon DI, Min KJ

Objectives The Korean Medication Algorithm Project for Depressive Disorder 2021 (KMAP-DD 2021) was made to update new researches and data. This study focused on non-pharmacological biological treatments. Methods Ninety-seven psychiatrists with...
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Comparison of Mismatch Negativity According to Suicidal Ideation in Patients With Major Depressive Disorder

Lee M, Lee YJ, Hwang J, Woo Si, Kim MJ, Kang B, Kim Y, Hahn SW

Objective : Mismatch negativity (MMN) is known to reflect several abnormalities of cognitive function-ing. This study is aimed to investigate the differences in MMN among major depressive disorder (MDD) patients...
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Alterations in the Occipital Cortex of Drug-Naïve Adults With Major Depressive Disorder: A Surface-Based Analysis of Surface Area and Cortical Thickness

Lee JS, Kang W, Kang Y, Kim A, Han KM, Tae WS, Ham BJ

Objective Advances in surface-based morphometric methods have allowed researchers to separate cortical volume into cortical thickness (CTh) and surface area (SA). Although CTh alterations in major depressive disorder (MDD) have...
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How Inflammation Affects the Brain in Depression: A Review of Functional and Structural MRI Studies

Han KM, Ham BJ

This narrative review discusses how peripheral and central inflammation processes affect brain function and structure in depression, and reports on recent peripheral inflammatory marker-based functional and structural magnetic resonance imaging...
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Trends in the Prevalence of Major Depressive Disorder by Sociodemographic Factors in Korea: Results from Nationwide General Population Surveys in 2001, 2006, and 2011

Lee J, Kim H, Hong JP, Cho SJ, Lee JY, Jeon HJ, Kim BS, Chang SM

Background: This study investigated trends in the prevalence of major depressive disorder (MDD) by sociodemographic factors in South Korea. Methods: National samples of the general population aged 18 years or older...
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Communication at the End of Life

Onishi H

End-of-life patients experience physical, mental, social, and existential distress. While medical personnel provide medication and care to alleviate patients’ distress, listening to and interacting with patients remains essential for understanding...
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Korean Medication Algorithm Project for Depressive Disorder 2021 (II): The Subtypes of Depression

Park YM, Seo JS, Woo YS, Bahk WM, Kim W, Jeong JH, Shim SH, Lee JG, Jang SH, Wang SM, Jung MH, Sung HM, Choo LH, Yoon BH, Lee SY, Jon DI, Min KJ

Objectives The Korean Medication Algorithm Project for Depressive Disorder (KMAP-DD) was developed in 2002 and revised in 2006, 2012, 2017. In 2021, the fifth edition was published. This edition reflected new...
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