Korean J Gynecol Oncol Colposc.
2004 Mar;15(1):3-14.
Analysis of Microsatellite Instability and hMLH1, hMSH2 and Bax Expression in Sporadic Endometrioid Endometrial Adenocarcinoma
- Affiliations
-
- 1Department of Obstetrics and Gynecology, Ewha Womans' University, Seoul, Korea.
- 2Department of Pathology, College of Medicine, Ewha Womans' University, Seoul, Korea.
- 3Department of Obstetrics and Gyneecology, Gangneung Asan Hospital, Gangneung, Korea.
Abstract
OBJECTIVE
: We aimed to assess the incidence and clinicopathologic significance of microsatellite instability (MSI) and to analyze the loss of protein expression of hMLH1, hMSH2 and Bax gene in endometrioid endometrial adenocarcinoma.
METHODS
: A total of 30 patients with pure endometrioid type of endometrial adenocarcinoma were examined. MSI analysis was done using five polymorphic markers (BAT26, D5S346, BAT25, D17S250, D2S123) and the protein expression of hMLH1, hMSH2 and Bax gene was determined using immunohistochemical staining.
RESULTS
: MSI was detected in 30% (9/30) of endometrioid endometrial adenocarcinoma. There was a significant correlation between MSI status and loss of hMLH1, hMSH2 and Bax expression (p<0.05). No significant association was found between MSI status and clinicopathologic factors, such as age, grade, stage, depth of myometrial invasion, lymph- vascular space invasion, lymph node involvement and peritoneal cytology (p>0.05). But there were significant correlations between loss of hMLH1 and histological grade and lymph-vascular space invasion of endometrial adenocarcinoma (p<0.05). No significant association was found between hMSH2, Bax and clinicopathologic factors (p>0.05).
CONCLUSION
: According to the results, MSI and loss of protein expression of hMLH1, hMSH2 and Bax could be associated with the pathogenesis of sporadic endometrioid endometrial adenocarcinoma. In addition, hMLH1 might have a role as a prognostic parameter. Further prospective study with a large number of cases is needed in future.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- hMLH1/hMSH2 Protein Expression in Sporadic Colorectal Carcinoma and Its Clinicopathological Significance
- Characterization of Mutator Pathway in Younger-age-onset Colorectal Adenocarcinomas
- Microsatellite Instability and Mismatch Repair Protein (hMLH1, hMSH2) Expression in Intrahepatic Cholangiocarcinoma
- Expression of hMSH2, hMLH1 Protein in Sporadic Colorectal Cancer and Corresponding Normal Tissue
- Analysis of Microsatellite Instability in Ovarian Epithelial Cancer
