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Usefulness of Immunohistochemistry for Microsatellite Instability Screening in Gastric Cancer

Bae YS, Kim H, Noh SH, Kim H

BACKGROUND/AIMS: The usefulness of immunohistochemistry to screen for the microsatellite instability (MSI) phenotype in gastric cancer remains unclear. Moreover, the prognostic value of MSI phenotypes in gastric cancer has been...
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hMLH1 promoter methylation and BRAF mutations in high-frequency microsatellite instability colorectal cancers not fulfilling the revised Bethesda guidelines

Kim SJ, Kim HR, Kim SH, Han JH, Cho YB, Yun SH, Lee WY, Kim HC

PURPOSE: Sporadic colorectal cancers with high-frequency microsatellite instability (MSI-H) are related to hypermethylation of mismatch repair (MMR) genes and a higher frequency of BRAF mutations than Lynch syndrome. We estimated...
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Overexpression of p53, Mutation of hMLH1 and Microsatellite Instability in Gastric Carcinomas: Clinicopathologic Implications and Prognosis

Kwon J, Lee JH, Jee YS, Park DJ, Kim HH, Lee HJ, Yang HK, Lee KU, Lee HS

PURPOSE: Mutated p53 is a tumor suppressor gene, hMLH1 is a mismatch repair gene, and hypermethylation of hMLH1 follows microsatellite instability (MSI). This research's aim is to investigate mutated p53,...
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Analysis of Microsatellite Instability in Ovarian Epithelial Cancer

Sol MY, Choi KU, Kim JY, Kang HJ, Shin DH, Kim ID, Choi HS, Seo SJ

  • KMID: 1521611
  • Korean J Pathol.
  • 2007 Dec;41(6):380-386.
BACKGROUND: The aim of this study was to clarify the incidence and role of microsatellite instability (MSI) in sporadic ovarian epithelial cancers (OEC). We investigated the MSI status and mismatch...
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Genetic Expression Pattern of Gastric Carcinomas According to Cellular Mucin Phenotypes

Lee WA, Suh IS, Li YH, Eum JH, Yu WS, Bae HI

  • KMID: 1521624
  • Korean J Pathol.
  • 2007 Oct;41(5):307-315.
BACKGROUND: Gastric carcinomas (GCs) have recently been reclassified according to the mucin phenotypes. We aimed to characterize the relationship between the mucin phenotypes and the genetic alterations or the clinicopathologic...
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Expression of beta-catenin, hMLH1, p53, Bcl-2, Bax and COX-2 in Serrated Adenomas of Colon

Choi KW, Jang BI, Eun JR, Lee JH, Bae YK, Kim TN

  • KMID: 2304819
  • Korean J Gastrointest Endosc.
  • 2007 Jan;34(1):19-27.
BACKGROUND/AIMS: Serrated adenoma of the colorectum is a recently proposed entity that is characterized by a saw-toothed structure of hyperplastic polyp and also the cytologic atypia of conventional adenoma. In...
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Efficacy of hMLH1/hMSH2 Immunohistochemical Staining as Representative Index for Microsatellite Instability Status in Sporadic Colorectal Cancer

Jung SH, Kim HC, Kim JS, Choi J, Yu CS, Kim JC

  • KMID: 2199241
  • J Korean Soc Coloproctol.
  • 2006 Jun;22(3):184-191.
PURPOSE: Sporadic colorectal cancer with micosatellite instability (MSI) is supposed to have a distinct molecular profile, distinct clinocopathologic feature, and a distinct prognosis. However, the test for MSI is still...
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Methylation Pattern of DNA Repair Genes and Microsatellite Instability in Hepatocelluar Carcinoma

Park JH, Cho SB, Lee WS, Park CH, Joo YE, Kim HS, Choi SK, Rew JS, Lee JH, Kim SJ

  • KMID: 1113480
  • Korean J Gastroenterol.
  • 2006 Nov;48(5):327-336.
BACKGROUND/AIMS: Epigenetic silencing of DNA repair genes, O6-methylguanine-DNA methyltransferase (MGMT), hMLH1 and hMSH3, by promoter hypermethylation have been observed in various cancers. However, the relationship between hypermethylation of DNA...
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Microsatellite Instability and Mismatch Repair Protein (hMLH1, hMSH2) Expression in Intrahepatic Cholangiocarcinoma

Kang YK, Kim WH

  • KMID: 2275436
  • Korean J Pathol.
  • 2005 Feb;39(1):9-14.
BACKGROUND: To clarify the role of the mismatch repair (MMR) system in the carcinogenesis of intrahepatic cholangiocarcinoma (ICC), we investigated the microsatellite instability (MSI) status and MMR protein expression in...
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Methylation of P16 and hMLH1 in Gastric Carcinoma

Sung GY, Chun KH, Kim JJ, Chin HM, Kim W, Park CH, Park SM, Lim KW, Park WB, Kim SN, Jeon HM

  • KMID: 2372787
  • J Korean Gastric Cancer Assoc.
  • 2005 Dec;5(4):228-237.
PURPOSE: We investigated the impacts of the methylation states of the P16 and the hMLH1 genes on pathogenesis and genetic expression of stomach cancer and their relationships with Helicobater pylori...
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Analysis of Microsatellite Instability and hMLH1, hMSH2 and Bax Expression in Sporadic Endometrioid Endometrial Adenocarcinoma

Park JE, Park HM, Ryu HJ, Lee SW, Han WS, Kim SC

  • KMID: 2244922
  • Korean J Gynecol Oncol Colposc.
  • 2004 Mar;15(1):3-14.
OBJECTIVE : We aimed to assess the incidence and clinicopathologic significance of microsatellite instability (MSI) and to analyze the loss of protein expression of hMLH1, hMSH2 and Bax gene in...
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Responsiveness of CPT-11 in Respect to hMLH1 and hMSH2 Protein Expression in the Primary Colorectal Cancer

Park IJ, Kim HC, Yu CS, Chang HM, Lee JH, Kim JH, Kim TW, Kim JS, Kim JC

  • KMID: 2166126
  • Cancer Res Treat.
  • 2004 Dec;36(6):360-366.
PURPOSE: The aim of this study was to evaluate the responsiveness to CPT-11 with respect to hMLH1 and hMSH2 protein expressions in primary colorectal tumors. MATERIAL AND METHODS: 91 patients...
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Microsatellite Instability and Promoter Methylation of hMLH1 in Sporadic Gastric Carcinoma

Kim HC, Roh SA, Yook JH, Oh ST, Kim BS, Yu CS, Kim JC

  • KMID: 2372717
  • J Korean Gastric Cancer Assoc.
  • 2003 Mar;3(1):50-55.
BACKGROUND: An aberrant function of the mismatch repair system has been reported to underlie carcinogenesis in several tumors, including colorectal and gastric carcinomas, and to induce the typical genotype of...
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hMLH1/hMSH2 Protein Expression in Sporadic Colorectal Carcinoma and Its Clinicopathological Significance

Kang JH, Lee KY, Lee KH, Yoon C, Oh SM, Lee JH

  • KMID: 2026051
  • J Korean Soc Coloproctol.
  • 2001 Feb;17(1):38-46.
PURPOSE: DNA replication errors (RERs) in repeated nucleotide sequences (microsatellite instability) is caused by defective mismatch repair (MMR) genes. Ninety percent of colorectal carcinomas in hereditary nonpolyposis colorectal cancer (HNPCC)...
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Hypermethylation of Tumor-related Genes in Genitourinary Cancer Cell Lines

Chung WB, Hong SH, Kim JA, Sohn YK, Kim BW, Kim JW

Hypermethylation of CpG island is a common mechanism for the inactivation of tumor-related genes. In the present study, we analyzed 13 genitourinary cancer cell lines for aberrant DNA methylation of...
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Expression of hMSH2, hMLH1 Protein in Sporadic Colorectal Cancer and Corresponding Normal Tissue

Jung JY, Park DK, Shin JH

  • KMID: 1835109
  • J Korean Soc Coloproctol.
  • 1998 Dec;14(4):709-718.
PURPOSE: DNA mismatch repair gene is responsible for hereditary nonpolyposis colorectal cancer. But it is not well known its role in sporadic colorectal cancer patients. We analysed normal hMSH2, hMLH1...
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