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The Clinical Significance of Microsatellite Instability in Patients with Right-sided Colorectal Cancer

Han SA, Kim JH, Choi JH, Lee DH, Jung K, Kim SE, Moon W, Park MI, Park SJ

BACKGROUND/AIMS: Colorectal cancer (CRC) with microsatellite instability (MSI) has a better prognosis than CRC with microsatellite stable (MSS). Recent studies have reported biological differences according to tumor location in CRC....
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Single Patient Classifier Assay, Microsatellite Instability, and Epstein-Barr Virus Status Predict Clinical Outcomes in Stage II/III Gastric Cancer: Results from CLASSIC Trial

Roh CK, Choi YY, Choi S, Seo WJ, Cho M, Jang E, Son T, Kim HI, Kim H, Hyung WJ, Huh YM, Noh SH, Cheong JH

PURPOSE: Clinical implications of single patient classifier (SPC) and microsatellite instability (MSI) in stage II/III gastric cancer have been reported. We investigated SPC and the status of MSI and Epstein-Barr...
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Clinical Implications of Microsatellite Instability in Early Gastric Cancer

Kim DG, An JY, Kim H, Shin SJ, Choi S, Seo WJ, Roh CK, Cho M, Son T, Kim HI, Cheong JH, Hyung WJ, Noh SH, Choi YY

PURPOSE: We aimed to evaluate the clinical characteristics of microsatellite instability in early gastric cancer. MATERIALS AND METHODS: The microsatellite instability status of resected early gastric tumors was evaluated using two...
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Clinical Utility of a Fully Automated Microsatellite Instability Test with Minimal Hands-on Time

Lee M, Chun SM, Sung CO, Kim SY, Kim TW, Jang SJ, Kim J

BACKGROUND: Microsatellite instability (MSI) analysis is becoming increasingly important in many types of tumor including colorectal cancer (CRC). The commonly used MSI tests are either time-consuming or labor-intensive. A fully...
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Prognostic Impact of Fusobacterium nucleatum Depends on Combined Tumor Location and Microsatellite Instability Status in Stage II/III Colorectal Cancers Treated with Adjuvant Chemotherapy

Oh HJ, Kim JH, Bae JM, Kim HJ, Cho NY, Kang GH

BACKGROUND: This study aimed to investigate the prognostic impact of intratumoral Fusobacterium nucleatum in colorectal cancer (CRC) treated with adjuvant chemotherapy. METHODS: F. nucleatum DNA was quantitatively measured in a total...
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BRAF-Mutated Colorectal Cancer Exhibits Distinct Clinicopathological Features from Wild-Type BRAF-Expressing Cancer Independent of the Microsatellite Instability Status

Jang MH, Kim S, Hwang DY, Kim WY, Lim SD, Kim WS, Hwang TS, Han HS

In patients with colorectal cancer (CRC), the BRAF V600E mutation has been reported to be associated with several clinicopathological features and poor survival. However, the prognostic implications of BRAF V600E...
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Prognostic Impact of Microsatellite Instability in Colorectal Cancer Presenting With Mucinous, Signet-Ring, and Poorly Differentiated Cells

Jung SH, Kim SH, Kim JH

PURPOSE: Mucinous cells (MUCs), signet-ring cells (SRCs), and poorly differentiated cells (PDCs) are uncommon histologic types and have been associated with advanced tumor stage and poor prognosis. However, MUCs, SRCs,...
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Impact of Microsatellite Instability in Signet-Ring Cell and Mucinous Components in Patients With Colorectal Carcinoma

Kim IY

No abstract available.
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hMLH1 promoter methylation and BRAF mutations in high-frequency microsatellite instability colorectal cancers not fulfilling the revised Bethesda guidelines

Kim SJ, Kim HR, Kim SH, Han JH, Cho YB, Yun SH, Lee WY, Kim HC

PURPOSE: Sporadic colorectal cancers with high-frequency microsatellite instability (MSI-H) are related to hypermethylation of mismatch repair (MMR) genes and a higher frequency of BRAF mutations than Lynch syndrome. We estimated...
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Is Microsatellite Instability Really a Good Prognostic Factor of Colorectal Cancer?

Shin US, Cho SS, Moon SM, Park SH, Jee SH, Jung EJ, Hwang DY

PURPOSE: The aim of this study was to investigate the clinicopathologic features of and the prognosis for colorectal cancers (CRCs) with microsatellite instabilities (MSIs). METHODS: Between 2006 and 2009, genotyping was...
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Is a Microsatellite Instability Still Useful for Tailored Treatment in Stage II and III Colon Cancer?

Kim NK

No abstract available.
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Microsatellite Instability in Invasive Ductal Carcinomas

Jeong DH, Jeong JC, Park CH, Kwon MJ, Cho SJ, Nam ES, Shin HS, Kim KS

PURPOSE: Breast cancer shows various molecular and genetic alterations in its development and progression. Microsatellite alterations, and especially microsatellite instability (MSI) and loss of heterozygosity (LOH), have recently been postulated...
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Tetranucleotide Repeat Microsatellite Instability in Uterine Cervical Carcinomas

Choi YD, Lee JS, Choi C, Park CS, Juhng SW, Choi HS, Nam JH

  • KMID: 1521692
  • Korean J Pathol.
  • 2007 Feb;41(1):30-37.
BACKGROUND: Elevated levels of microsatellite alterations at selected tetranucleotide repeat regions (EMAST) have been recently described, and they are a distinct type of microsatellite instability (MSI). We investigated the prevalence...
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Analysis of Microsatellite Instability in Ovarian Epithelial Cancer

Sol MY, Choi KU, Kim JY, Kang HJ, Shin DH, Kim ID, Choi HS, Seo SJ

  • KMID: 1521611
  • Korean J Pathol.
  • 2007 Dec;41(6):380-386.
BACKGROUND: The aim of this study was to clarify the incidence and role of microsatellite instability (MSI) in sporadic ovarian epithelial cancers (OEC). We investigated the MSI status and mismatch...
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Microsatellite instability in mongolian gerbils induced by Helicobacter pylori

Park DI, Kim MK, Kim JJ, Yoo TW, Park JH, Kim HJ, Cho YK, Sohn CI, Jeon WK, Kim BI

  • KMID: 2256647
  • Korean J Med.
  • 2006 Jul;71(1):17-23.
BACKGROUND: During Helicobacter pylori (HP) gastritis, the organisms cause an impairment of DNA repair that results in accumulation of mutations in the genome of epithelial cells and an increased risk...
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Efficacy of hMLH1/hMSH2 Immunohistochemical Staining as Representative Index for Microsatellite Instability Status in Sporadic Colorectal Cancer

Jung SH, Kim HC, Kim JS, Choi J, Yu CS, Kim JC

  • KMID: 2199241
  • J Korean Soc Coloproctol.
  • 2006 Jun;22(3):184-191.
PURPOSE: Sporadic colorectal cancer with micosatellite instability (MSI) is supposed to have a distinct molecular profile, distinct clinocopathologic feature, and a distinct prognosis. However, the test for MSI is still...
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Microsatellite instability analysis on epithelial ovarian tumor

Kim SS, Park IS

  • KMID: 2143515
  • Korean J Gynecol Oncol.
  • 2006 Dec;17(4):302-309.
OBJECTIVE: Some genetic alterations are involved in ovarian carcinogenesis. Since some benign and borderline tumors may represent early steps in ovarian carcinogenesis, analysis of precursor lesions could provide evidence that...
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A Study of Microsatellite Instability of Upper Urinary Tract Transitional Cell Carcinoma

Kang TW, Lee JG, Jung SI, Choi YD, Choi C, Kwon DD, Park K, Ryu SB, Park YI

PURPOSE: The objective of this study was to evaluate the role of microsatellite instability (MSI) in upper tract transitional cell carcinomas (TCC). MATERIALS AND METHODS: A total of 48 surgically...
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Clinicopathological Significance of Microsatellite Instability in Sporadic Colorectal Cancer

Oh SY, Lee JM, Lee HW, Kim YB, Cheong SH, Kim JM, Suh KW

  • KMID: 2096381
  • J Korean Surg Soc.
  • 2006 Dec;71(6):420-425.
PURPOSE: Many studies have demonstrated that sporadic MSI-H colorectal cancers share several clinicopathological features with hereditary nonpolyposis colorectal cancers. However, microsatellite instability (MSI) in HNPCC and sporadic colorectal cancer occur...
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Relationship between Microsatellite Instability and Dihydropyrimidine Dehydrogenase Expression as a Predictor of Response to 5-Fluorouracil Chemotherapy for Colorectal Cancer

Rhyou JH, Lee SH, Lee WI, Lee RA, Kim KH, Chung SS, Park EB

  • KMID: 2101392
  • J Korean Soc Coloproctol.
  • 2005 Jun;21(3):157-166.
PURPOSE: Dihydropyrimidine dehydrogenase (DPD) is a rate-limiting enzyme in 5-FU catabolism, so the enzymatic activity of DPD reflects the 5-FU response. Moreover, recent studies have revealed that microsatellite instability (MSI)...
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