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Usefulness of Immunohistochemistry for Microsatellite Instability Screening in Gastric Cancer

Bae YS, Kim H, Noh SH, Kim H

BACKGROUND/AIMS: The usefulness of immunohistochemistry to screen for the microsatellite instability (MSI) phenotype in gastric cancer remains unclear. Moreover, the prognostic value of MSI phenotypes in gastric cancer has been...
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Analysis of Microsatellite Instability in Ovarian Epithelial Cancer

Sol MY, Choi KU, Kim JY, Kang HJ, Shin DH, Kim ID, Choi HS, Seo SJ

  • KMID: 1521611
  • Korean J Pathol.
  • 2007 Dec;41(6):380-386.
BACKGROUND: The aim of this study was to clarify the incidence and role of microsatellite instability (MSI) in sporadic ovarian epithelial cancers (OEC). We investigated the MSI status and mismatch...
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Efficacy of hMLH1/hMSH2 Immunohistochemical Staining as Representative Index for Microsatellite Instability Status in Sporadic Colorectal Cancer

Jung SH, Kim HC, Kim JS, Choi J, Yu CS, Kim JC

  • KMID: 2199241
  • J Korean Soc Coloproctol.
  • 2006 Jun;22(3):184-191.
PURPOSE: Sporadic colorectal cancer with micosatellite instability (MSI) is supposed to have a distinct molecular profile, distinct clinocopathologic feature, and a distinct prognosis. However, the test for MSI is still...
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Microsatellite Instability and Mismatch Repair Protein (hMLH1, hMSH2) Expression in Intrahepatic Cholangiocarcinoma

Kang YK, Kim WH

  • KMID: 2275436
  • Korean J Pathol.
  • 2005 Feb;39(1):9-14.
BACKGROUND: To clarify the role of the mismatch repair (MMR) system in the carcinogenesis of intrahepatic cholangiocarcinoma (ICC), we investigated the microsatellite instability (MSI) status and MMR protein expression in...
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Analysis of Microsatellite Instability and hMLH1, hMSH2 and Bax Expression in Sporadic Endometrioid Endometrial Adenocarcinoma

Park JE, Park HM, Ryu HJ, Lee SW, Han WS, Kim SC

  • KMID: 2244922
  • Korean J Gynecol Oncol Colposc.
  • 2004 Mar;15(1):3-14.
OBJECTIVE : We aimed to assess the incidence and clinicopathologic significance of microsatellite instability (MSI) and to analyze the loss of protein expression of hMLH1, hMSH2 and Bax gene in...
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Responsiveness of CPT-11 in Respect to hMLH1 and hMSH2 Protein Expression in the Primary Colorectal Cancer

Park IJ, Kim HC, Yu CS, Chang HM, Lee JH, Kim JH, Kim TW, Kim JS, Kim JC

  • KMID: 2166126
  • Cancer Res Treat.
  • 2004 Dec;36(6):360-366.
PURPOSE: The aim of this study was to evaluate the responsiveness to CPT-11 with respect to hMLH1 and hMSH2 protein expressions in primary colorectal tumors. MATERIAL AND METHODS: 91 patients...
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hMLH1/hMSH2 Protein Expression in Sporadic Colorectal Carcinoma and Its Clinicopathological Significance

Kang JH, Lee KY, Lee KH, Yoon C, Oh SM, Lee JH

  • KMID: 2026051
  • J Korean Soc Coloproctol.
  • 2001 Feb;17(1):38-46.
PURPOSE: DNA replication errors (RERs) in repeated nucleotide sequences (microsatellite instability) is caused by defective mismatch repair (MMR) genes. Ninety percent of colorectal carcinomas in hereditary nonpolyposis colorectal cancer (HNPCC)...
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Microsatellite Instability and hMSH2 Gene Mutations in Sporadic Colorectal Cancers

Jeon HM, Oh ST, Kim JS, Chang SK, Kim JS

  • KMID: 2101319
  • J Korean Soc Coloproctol.
  • 1998 Mar;14(1):41-49.
Microsatellites are short nucleotide repeat sequences present throughout the human genome. Alterations of microsatellites, comprising extra or missing copies of these se quences, have been termed microsatellite instability(MSI, genetic instability,...
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Expression of hMSH2, hMLH1 Protein in Sporadic Colorectal Cancer and Corresponding Normal Tissue

Jung JY, Park DK, Shin JH

  • KMID: 1835109
  • J Korean Soc Coloproctol.
  • 1998 Dec;14(4):709-718.
PURPOSE: DNA mismatch repair gene is responsible for hereditary nonpolyposis colorectal cancer. But it is not well known its role in sporadic colorectal cancer patients. We analysed normal hMSH2, hMLH1...
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