Korean J Anesthesiol.  2001 Feb;40(2):238-243. 10.4097/kjae.2001.40.2.238.

Neuroprotective Effects of Propofol, Ketamine and Propofol-ketamine after Transient Forebrain Ischemia in the Rat

• Kwon JY
• Jeon JH
• Chung KS
• Kim IS
• Baik SW
• Kim HK

• KMID: 2236829
• DOI: http://doi.org/10.4097/kjae.2001.40.2.238

Abstract

BACKGROUND: Intravenous anesthetics such as propofol and ketamine have been known to have neuroprotective effects. However, the combination of these drug is not known. This study was conducted to determine the neuroprotective effects of propofol, ketamine or both after transient forebrain ischemia.
METHODS
Twenty Sprague-Dawley rats (250-300 gm) were used. Anesthesia was induced with 4% isoflurane in oxygen and then maintained with 1 - 2% isoflurane in oxygen. Ischemic injury was induced by 10 minutes of both common carotid artery ligation and hypotension (MAP < 50 mmHg). All rats were randomly divided into four groups: group I; control group; group II; ketamine 10 mg/kg was administered 10 minutes before injury; group III; propofol (1 mg/kg/min) was administered until EEG isoelectricity; and group IV; ketamine 10 mg/kg and propofol 1 mg/kg/min was administered. The Rectal temperature was maintained at 38oC. After forebrain ischemia, neurologic scores were estimated at 1 hr, 2 hrs, 1 day and 2 days after recovery. The brain was removed 3 days after and stained with H-E stain.
RESULTS
Neurologic and histologic scores of group II, III, IV were significantly lower than that of group I. However, there were no significant difference between group II, III and IV.
CONCLUSIONS
Ketamine and propofol have neuroprotective effects in transient forebrain ischemia in rats. However, the combination of propofol and ketamine did not show any synergistic or additive effects.

Keyword

Animal: rats; Anesthetics, intravenous: ketamine; propofol; Brain: ischemic injury

MeSH Terms

Anesthesia
Anesthetics, Intravenous
Animals
Brain
Carotid Artery, Common
Electroencephalography
Hypotension
Ischemia*
Isoflurane
Ketamine*
Ligation
Neuroprotective Agents*
Oxygen
Propofol*
Prosencephalon*
Rats*
Rats, Sprague-Dawley
Anesthetics, Intravenous
Isoflurane
Ketamine
Neuroprotective Agents
Oxygen
Propofol