J Korean Soc Biol Psychiatry.  2003 Nov;10(2):177-185.

Prolactin Response to Antipsychotic Drug and Dopamine Transporter Gene Polymorphisms

• Lee BH
• Kim YK
• Suh KY

Abstract

OBJECT: We investigated the relationship between prolactin response to antipsychotics and clinical courses of psychotic symptoms and DAT gene polymorphisms. METHOD: Twenty-four acute psychotic inpatients completed the 12-week trial of risperidone. Serum prolactin, BPRS, ESRS and hyperprolactinemia-related symptoms were measured at baseline, 2, 4, 8 and 12 weeks after medication. The DAT gene polymorphisms were analyzed.
RESULTS
The serum prolactin was significantly increased over time. According to the prolactin level at 2-week, the subjects were divided into the severe group(serum prolactin>60ng/mL, N=15) and the mild group (serum prolactin<60ng/mL, N=9). The prolactin levels of the mild group didn't increase beyond 60ng/mL throughout 12 weeks. Severe group had slower decrement of BPRS scores than those of mild group. Six females in severe group complained of irregular menstruations, but no female in mild group. Most patients had 10 allele of DAT gene.
CONCLUSION
This study suggests that the magnitude of prolactin elevation at the 2-week of risperidone medication is correlated with severity of hyperprolactinemia throughout treatments. Our results did not show the relationship between prolactin responses and DAT gene polymorphisms.

MeSH Terms

Alleles
Antipsychotic Agents
Bipolar Disorder
Dopamine Plasma Membrane Transport Proteins*
Dopamine*
Female
Humans
Hyperprolactinemia
Inpatients
Menstruation
Prolactin*
Risperidone
Schizophrenia
Antipsychotic Agents
Dopamine
Dopamine Plasma Membrane Transport Proteins
Prolactin
Risperidone