J Korean Rheum Assoc.  2009 Jun;16(2):87-94. 10.4078/jkra.2009.16.2.87.

Bone Marrow Findings, and TNF-alpha, IL-18 Expression in Bone Marrow of Adult Onset Still's Disease Patients

• Jung KH
• Kim HY
• Son CN
• Kim JH
• Kim WJ
• Lee KA
• Park HH
• Lee WS
• Yoo DH

• KMID: 2202123
• DOI: http://doi.org/10.4078/jkra.2009.16.2.87

Abstract

OBJECTIVE
Inflammatory cytokines may play important roles in the pathogenesis of adult onset Still's disease. The enhanced expression of IL-18 was reported in the bone marrow of a Japanese systemic onset juvenile rheumatoid arthritis patient but not in the other organs. To date, there are very few studies relating the bone marrow and AOSD. This study examined the bone marrow findings as well as TNF-alpha and IL-18 expression in the bone marrow of AOSD patients.
METHODS
A retrospective study was performed on 15 AOSD patients who had undergone a bone marrow examination at a university hospital. The clinical and laboratory findings, as well as the bone marrow findings, were analyzed. Immunohistochemistry of IL-18 and TNF-alpha in bone marrow was performed.
RESULTS
The bone marrow cellularity and myeloid/erythroid cell ratio showed no correlation with the clinical and laboratory findings. TNF-alpha was expressed at 0.8~9.8% and IL-18 was expressed at 0.4~9.8% of bone marrow cells. Cytokine expression was not associated with the clinical patterns of AOSD. The platelet count correlated with the bone marrow TNF-alpha expression but TNF-alpha did not correlate with IL-18 expression.
CONCLUSION
TNF-alpha and IL-18 expression in bone marrow were observed in some AOSD patients but there was no correlation with the other clinical and laboratory findings except for the platelet count.

Keyword

Adult onset Still's disease; Tumor necrosis factor-alpha; Interleukin-18; Bone marrow

MeSH Terms

Adult
Arthritis, Juvenile Rheumatoid
Asian Continental Ancestry Group
Bone Marrow
Bone Marrow Cells
Bone Marrow Examination
Cytokines
Humans
Immunohistochemistry
Interleukin-18
Platelet Count
Retrospective Studies
Still's Disease, Adult-Onset
Tumor Necrosis Factor-alpha
Cytokines
Interleukin-18
Tumor Necrosis Factor-alpha

Figure

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  Fig. 1. Correlation between bone marrow TNF-α expression and platelet counts (The correlation coefficient was analyzed by Sperman's rank correlation test. n=15, r=0.578, p＜0.005).

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  Fig. 2. Correlation between bone marrow TNF-α and IL-18 expression (r=0.417, p=0.122).

Reference

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