J Korean Soc Ther Radiol Oncol.
2007 Dec;25(4):242-248.
The Effect of Recombinant Human Epidermal Growth Factor on Cisplatin and Radiotherapy Induced Oral Mucositis in Mice
- Affiliations
-
- 1Department of Diagnostic Radiology, Gyeongsang National University School of Medicine, Jinju, Korea.
- 2Department of Pharmacology, Gyeongsang National University School of Medicine, Jinju, Korea. jsk92@gnu.ac.kr
- 3Department of Radiation Oncology, Gyeongsang National University School of Medicine, Jinju, Korea.
- 4Department of Radiation Oncology, University of Ulsan College of Medicine, Seoul, Korea.
- 5Department of Radiation Oncology, Wonkwang University College of Medicine, Iksan, Korea.
- 6Department of Radiation Oncology, The Catholic University of Korea College of Medicine, Seoul, Korea.
Abstract
-
PURPOSE: To study the effect of recombinant human epidermal growth factor (rhEGF) on oral mucositis induced by cisplatin and radiotherapy in a mouse model.
MATERIALS AND METHODS
Twenty-four ICR mice were divided into three groups? the normal control group, the no rhEGF group (treatment with cisplatin and radiation) and the rhEGF group (treatment with cisplatin, radiation and rhEGF). A model of mucositis induced by cisplatin and radiotherapy was established by injecting mice with cisplatin (10 mg/kg) on day 1 and with radiation exposure (5 Gy/day) to the head and neck on days 1~5. rhEGF was administered subcutaneously on days -1 to 0 (1 mg/kg/day) and on days 3 to 5 (1 mg/kg/day). Evaluation included body weight, oral intake, and histology.
RESULTS
For the comparison of the change of body weight between the rhEGF group and the no rhEGF group, a statistically significant difference was observed in the rhEGF group for the 5 days after day 3 of the experiment. The rhEGF group and no rhEGF group had reduced food intake until day 5 of the experiment, and then the mice demonstrated increased food intake after day 13 of the of experiment. When the histological examination was conducted on day 7 after treatment with cisplatin and radiation, the rhEGF group showed a focal cellular reaction in the epidermal layer of the mucosa, while the no rhEGF group did not show inflammation of the oral mucosa.
CONCLUSION
These findings suggest that rhEGF has a potential to reduce the oral mucositis burden in mice after treatment with cisplatin and radiation. The optimal dose, number and timing of the administration of rhEGF require further investigation.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Effects of Recombinant Human Epidermal Growth Factor (rhEGF) on Experimental Radiation-Induced Oral Mucositis in Rats
- Two Cases of Acneiform Eruption Caused by Epidermal Growth Factor Receptor Inhibitors
- Targeted Molecular Therapy in a Murine Model of Oral Squamous Cell Carcinoma with an Epidermal Growth Factor Receptor Inhibitor
- Effect of Sucralfate of the Prophylaxia of Adriamycin Induced Mucositis in the Rat
- Prognostic significance of epidermal growth factor receptor expression in human gastric carcinoma
