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Neovascular Glaucoma with Ocular Ischemia in Superior Vena Cava Syndrome

Jeon JH, Cho KJ, Chang KC, Chang MH

PURPOSE: To report a case of neovascular glaucoma (NVG) with ocular ischemia in superior vena cava syndrome (SVCS). CASE SUMMARY: A 57-year old male who had been treated for small cell...
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Resveratrol activates AMPK and suppresses LPS-induced NF-kappaB-dependent COX-2 activation in RAW 264.7 macrophage cells

Yi CO, Jeon BT, Shin HJ, Jeong EA, Chang KC, Lee JE, Lee DH, Kim HJ, Kang SS, Cho GJ, Choi WS, Roh GS

AMP-activated protein kinase (AMPK), an enzyme involved in energy homeostasis, regulates inflammatory responses, but its precise mechanisms are not fully understood. Recent evidence has shown that resveratrol (RES), an AMPK...
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Indigo carmine enhances phenylephrine-induced contractions in an isolated rat aorta

Choi YS, Ok SH, Lee SM, Park SS, Ha YM, Chang KC, Kim HJ, Shin IW, Sohn JT

BACKGROUND: The intravenous administration of indigo carmine has been reported to produce transiently increased blood pressure in patients. The goal of this in vitro study was to examine the effect...
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Traumatic Eyeball Protrusion with Optic Chiasmal Injury

Lee SM, Chang KC, Chang MH

PURPOSE: To report a case of eyeball protrusion with optic chiasmal injury due to eyeball trauma. CASE SUMMARY: A 59-year-old male presented to the emergency room for right eyeball pain, eyeball...
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Genipin Selectively Inhibits TNF-alpha-activated VCAM-1 But Not ICAM-1 Expression by Upregulation of PPAR-gamma in Human Endothelial Cells

Hwa JS, Mun L, Kim HJ, Seo HG, Lee JH, Kwak JH, Lee DU, Chang KC

Vascular inflammation process has been suggested to be an important risk factor in the development of atherosclerosis. Recently we reported that induction of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) selectively inhibits vascular...
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C-Jun NH2-Terminal Kinase Contributes to Dexmedetomidine-Induced Contraction in Isolated Rat Aortic Smooth Muscle

Ok SH, Jeong YS, Kim JG, Lee SM, Sung HJ, Kim HJ, Chang KC, Kwon SC, Sohn JT

PURPOSE: Dexmedetomidine, a full agonist of alpha2B-adrenoceptors, is used for analgesia and sedation in the intensive care units. Dexmedetomidine produces an initial transient hypertension due to the activation of post-junctional...
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The Epidemiology of Cosmetic Treatments for Corneal Opacities in a Korean Population

Chang KC, Kwon JW, Han YK, Wee WR, Lee JH

PURPOSE: To describe etiologies and clinical characteristics of corneal opacities leading patients to seek cosmetic treatments. METHODS: The medical records of 401 patients who presented for cosmetic improvement in corneal...
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Corneal Endothelial Changes Induced by Corneal Bee Sting Injury

Park JK, Chang KC

  • KMID: 2337819
  • J Korean Ophthalmol Soc.
  • 2010 Mar;51(3):435-439.
PURPOSE: Corneal bee sting is a relatively rare injury. The authors report the significant endothelial changes despite complete resolution of corneal injury after a corneal bee sting. CASE SUMMARY: Two males,...
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Methazolamide-induced Stevens-Johnson Syndrome

Seo YS, Chang KC, Chang MH

PURPOSE: To report three consecutive cases of methazolamide-induced Stevens-Johnson syndrome. CASE SUMMARY: We describe three patients who were all prescribed methazolamide for treatment of ophthalmologic conditions. A 29-year-old man and a...
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DHA and EPA Down-regulate COX-2 Expression through Suppression of NF-kappa B Activity in LPS-treated Human Umbilical Vein Endothelial Cells

Lee SA, Kim HJ, Chang KC, Baek JC, Park JK, Shin JK, Choi WJ, Lee JH, Paik WY

Inflammatory processes of vascular endothelial cells play a key role in the development ofatherosclerosis. We determined the anti-inflammatory effects and mechanisms of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on...
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Preliminary Effects of Oral Uridine on the Ocular Surface in Dry Eye Patients

Chang KC, Oh JY, In YS, Kim MK, Shin KC, Wee WR, Lee JH, Park MG

We designed a randomized, double blinded, 3-months controlled prospective clinical study to investigate effects of oral uridine on the ocular surface in dry eye patients. Twenty-seven patients who diagnosed as...
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Introduction to Distribution and Ecology of Sterile Conks of Inonotus obliquus

Lee MW, Hur H, Chang KC, Lee TS, Ka KH, Jankovsky

Inonotus obliquus is a fungus that causes white heart rot on several broad-leaved species. This fungus forms typical charcoal-black, sterile conks (chaga) or cinder conks on infected stems of the...
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Orbital Cellulitis With Subperisoteal Abscess Secondary to Dental Extraction

Chang KC

  • KMID: 2337745
  • J Korean Ophthalmol Soc.
  • 2008 Nov;49(11):1845-1849.
PURPOSE: We report a case of orbital cellulitis with subperiosteal abscess secondary to dental extraction. CASE SUMMARY: A 55-year-old man presented to the emergency department with severe erythematous, painful swelling of...
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Kinetic Changes of COX-2 Expression during Reperfusion Period after Ischemic Preconditioning Play a Role in Protection Against Ischemic Damage in Rat Brain

Kang YJ, Park MK, Lee HS, Choi HC, Lee KY, Kim HJ, Seo HG, Lee JH, Chang KC

A brief ischemic insult induces significant protection against subsequent massive ischemic events. The molecular mechanisms known as preconditioning (PC)-induced ischemic tolerance are not completely understood. We investigated whether kinetic changes...
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The Effect of Recombinant Human Epidermal Growth Factor on Cisplatin and Radiotherapy Induced Oral Mucositis in Mice

Na JB, Kim HJ, Chai GY, Lee SW, Lee KK, Chang KC, Choi BO, Jang HS, Jeong BK, Kang KM

  • KMID: 2198501
  • J Korean Soc Ther Radiol Oncol.
  • 2007 Dec;25(4):242-248.
PURPOSE: To study the effect of recombinant human epidermal growth factor (rhEGF) on oral mucositis induced by cisplatin and radiotherapy in a mouse model. MATERIALS AND METHODS: Twenty-four ICR mice were...
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Induction of Heme Oxygenase-1 by Traditional Herb Mix Extract Improves MKN-74 Cell Survival and Reduces Stomach Bleeding in Rats by Ethanol and Aspirin in vivo

Kang YJ, Moon HS, Kim HJ, Seo HG, Lee JH, Chang KC

  • KMID: 1512909
  • Korean J Physiol Pharmacol.
  • 2007 Apr;11(2):65-70.
Chinese herb medicines have traditionally been used to treat or alleviate the symptom of various diseases. The rationale for use of certain herbs to certain disorder is now getting unveiled...
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The Fruiting Body Formation of Armillaria mellea on Oak Sawdust Medium Covered with Ground Raw Carrots

Shim JO, Chang KC, Lee YS, Park CH, Kim HY, Lee UY, Lee TS, Lee MW

  • KMID: 2312497
  • Mycobiology.
  • 2006 Dec;34(4):206-208.
To produce an artificial fruiting body of Armillaria mellea on the oak sawdust medium, seven strains of A. mellea were used. The top surface of oak sawdust medium covered with...
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The Fruiting Body Formation of Oudemansiella radicata in the Sawdust of Oak (Quercus variabilis) Mixed with Rice Bran

Shim JO, Chang KC, Kim TH, Lee YS, Lee UY, Lee TS, Lee MW

To screen additives and their mixed ratio suitable for the mycelial growth and fruiting body formation of Oudemansiella radicata in the oak sawdust, additives such as rice bran, fermented soybean...
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YS 49, a Synthetic Isoquinoline Alkaloid, Protects Sheep Pulmonary Artery Endothelial Cells from tert-butylhydroperoxide-mediated Cytotoxicity

Chong WS, Kang SY, Kang YJ, Park MK, Lee YS, Kim HJ, Seo HG, Lee JH, Yun-Choi H, Chang KC

  • KMID: 1600111
  • Korean J Physiol Pharmacol.
  • 2005 Oct;9(5):283-289.
Endothelium, particularly pulmonary endothelium, is predisposed to injury by reactive oxygen species (ROS) and their derivatives. Heme oxygenase (HO) has been demonstrated to provide cytoprotective effects in models of oxidant-induced...
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Inhibition of Inducible Nitric Oxide Synthase Expression by YS 49, a Synthetic Isoquinoline Alkaloid, in ROS 17/2.8 Cells Activated with TNF-alpha, IFN-gamma and LPS

Kang YJ, Kang SY, Lee YS, Park MK, Kim HJ, Seo HG, Lee JH, Yun-Choi H, Chang KC

  • KMID: 1611431
  • Korean J Physiol Pharmacol.
  • 2004 Oct;8(5):273-280.
Nitric oxide (NO) has been suggested to act as a mediator of cytokine-induced effects of turn over of bone. Activation of the inducible nitric oxide synthase (iNOS) by inflammation has...
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