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Differences in Body Weight, Dietary Efficiency, Brain Obesity Control Factor (AMPK), Reactive Oxygen Species (MDA), and Antioxidant Enzymes (SOD) in Young Mice According to the Intensity of Aerobic Exercise for 8 Weeks

Jeon MY

Purpose: The goal of this study was to see how different aerobic exercise intensities affected AMP-activated protein kinase (AMPK), reactive oxygen, and antioxidant enzymes in young mice during an 8-week...
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Intravenous Administration of Toll-Like Receptor Inhibitory Peptide 1 is Effective for the Treatment of Systemic Lupus Erythematosus in a Mus musculus Model

Baek WY, Lee SM, Lee SW, Son IO, Choi S, Suh CH

Objective Systemic lupus erythematosus (SLE) is a common chronic autoimmune inflammatory disease. According to recent studies, signaling through Toll-like receptor (TLR) protein, which promotes the production of inflammatory cytokines, leads...
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Effects of photobiomodulation on different application points and different phases of complex regional pain syndrome type I in the experimental model

Canever JB, Barbosa RI, Hendler KG, Neves LMSd, Kuriki HU, Aguiar Júnior AS, Registro Fonseca MdC, Márcio Marcolino A

Background: Complex regional pain syndrome type I (CRPS-I) consists of disorders caused by spontaneous pain or induced by some stimulus. The objective was to verify the effects of photobiomodulation (PBM)...
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Comparison of decomposition rate of hind limbs of preserved mice with ethanol-glycerin and formaldehyde of advanced fixative solution

Wijaya AN, Margiana R, Kusumaningtyas S, Furqonita D

Learning anatomy in medical school is still closely based on the use of cadavers. The burial of preserved cadaver poses a problem, specifically, it contaminates the soil with formalin. Many...
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Extract of Curcuma zedoaria R. prevents atherosclerosis in apolipoprotein E-deficient mice

Kim KM, Lee JY, Jeon BH, Quan KT, Na M, Nam KW, Chae S

BACKGROUND/OBJECTIVES: Curcuma zedoaria R. (Zingiberaceae) has been used to treat headache, fever, and hypertension-related symptoms in Asian countries, including Korea, China, and Japan. We investigated whether dietary intake of a...
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The protective effects of steamed ginger on adipogenesis in 3T3-L1 cells and adiposity in diet-induced obese mice

Kim B, Kim HJ, Cha YS

BACKGROUND/OBJECTIVES: The steamed ginger has been shown to have antioxidative effects and a protective effect against obesity. In the present study, we investigated the effects of ethanolic extract of steamed...
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Distinct Repopulation Activity in Hu-Mice between CBand LPB-CD34 Cells by Enrichment of Transcription Factors

Han AR, Lee JE, Lee MJ, Ko SY, Shin HS, Lee JY, Lee DR

Background and Objectives: Human CD34+hematopoietic stem cells can reconstitute the human hematopoietic system when transplanted into immunocompromised mice after irradiation. Human leukapheresis peripheral blood (LPB)-and cord blood (CB)-derived CD34+ cells...
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MondoA Is Required for Normal Myogenesis and Regulation of the Skeletal Muscle Glycogen Content in Mice

Ran H, Lu Y, Zhang Q, Hu Q, Zhao J, Wang K, Tong X, Su Q

Background Skeletal muscle is the largest tissue in the human body, and it plays a major role in exerting force and maintaining metabolism homeostasis. The role of muscle transcription factors in...
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Effect of pregabalin on nociceptive thresholds and immune responses in a mouse model of incisional pain

Park JH, Cho SH, Kim R, Na SH, Kang Es, Yeom My, Jang Y

Background: It is known that some analgesics as well as pain can affect the immune system. The aim of this study was to investigate the analgesic effect and immunomodulation of...
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Effects of the fermented Zizyphus jujuba in the amyloid β25-35 -induced Alzheimer's disease mouse model

Kim MJ, Jung JE, Lee S, Cho EJ, Kim HY

BACKGROUD/OBJECTIVES: Alzheimer's disease (AD) is the most common cause of dementia in the elderly. Due to the increased incidence of dementia, there is a corresponding increase concerning the importance of...
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Celecoxib, a selective cyclooxygenase-2 inhibitor, aggravates radiation-induced intestinal damage in mice

Lee S, Chun JM, Lee JH, Seo YS, Park JH, Lee HJ, Moon C, Kim SH, Kim JS

Celecoxib, a cyclooxygenase (COX)-2 selective inhibitor, was approved as a non-steroidal anti-inflammatory drug (NSAID), and this therapeutic application has been expanded to several other diseases, including colon cancer. Notably, a...
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Establishment of inflammatory model induced by Pseudorabies virus infection in mice

Ren CZ, Hu WY, Zhang JW, Wei YY, Yu ML, Hu TJ

Background: Pseudorabies virus (PRV) infection leads to high mortality in swine. Despite extensive efforts, effective treatments against PRV infection are limited. Furthermore, the inflammatory response induced by PRV strain GXLB-2013...
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Protective effects of curcumin on chromatin quality, sperm parameters, and apoptosis following testicular torsion-detorsion in mice

Shahedi A, Talebi AR, Mirjalili A, Pourentezari M

Objective: The chief outcome of testicular torsion in clinical and experimental contexts is testicular ischemia. Curcumin, a compound with anti-inflammatory and antioxidant properties, has fascinated researchers and clinicians for its...
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Effects of different intensities of exercise on folliculogenesis in mice: Which is better?

Rahayu FK, Dwiningsih SR, Sa’adi A, Herawati L

Objective: Exercise is a risk factor for infertility in women. However, research on the effects of different intensities of exercise on folliculogenesis has not yielded clear results. This study was...
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Effect Neonatal Ketamine Treatment on Exploratory and Anxiety-like Behaviours in Adulthood

Akillioglu K, Karadepe M

Objective: In this study, we evaluated the effect of neonatal ketamine exposure on anxiety-like and exploratory behaviours in adult the Balb/c and C57BL/6 strains of mice which anxiety responses are...
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Rapid Way to Generate Mouse Models for In Vivo Studies of the Endothelium

Lee H

A single layer of squamous endothelial cells (ECs), the endothelium, regulates the flow of substance and fluid into and out of a tissue. The endothelium is also involved in vasculogenesis,...
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Cryopreservation of mouse resources

Takeo T, Nakao S, Nakagawa Y, Sztein JM, Nakagata N

The cryopreservation of sperm and embryos is useful to efficiently archive valuable resources of genetically engineered mice. Till date, more than 60,000 strains of genetically engineered mice have been archived...
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Comparative analysis of restraint stress-induced depressive-like phenotypes in C57BL/6N mice derived from three different sources

Hwang DJ, Kwon KC, Hwang DY, Seo MS, Kim KS, Jung YS, Cho JY

C57BL/6NKorl mice are a novel mouse stock recently developed by the National Institute of Food and Drug Safety Evaluation in Korea. Extensive research into the nature of C57BL/6NKorl mice is...
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Development of chitosan-catechol conjugates as mucoadhesive polymer: assessment of acute oral toxicity in mice

Kaur L, Raj R, Thakur AK, Singh I

Development of modified polymers is the focused area of research for developing stable, effective, sustainable and economical polymeric materials for developing different drug delivery systems. Modification of chitosan by catechol...
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Characterization of changes in global gene expression in the hearts and kidneys of transgenic mice overexpressing human angiotensin-converting enzyme 2

Lee SH, Jee SW, Hwang DY, Kang JK

Human angiotensin-converting enzyme 2 (hACE2) has recently received a great attention due to it play a critical role as SARS-CoV receptor in the infection of human body. However, no further...
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