J Korean Assoc Maxillofac Plast Reconstr Surg.
2003 Nov;25(6):573-577.
Gingival overgrowth induced by immunosuppressant: case report
- Affiliations
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- 1Division of Oral & Maxillofacial Suregry, Department of Dentistry, College of Medicine, Hanyang University, Korea. hkg@hanyang.ac.kr
Abstract
- The gingival overgrowth was induced by several factors : phenytoin, nifedipine, cyclosporine, unsanitary oral hygiene, orthodontic appliances, and other diseases. It was also found in organ transplantation recipients using immunosuppressant. Gingival overgrowth and concomitant gingival bleeding may increase the risk for oral infections, resulting in reduced quality of life. Cyclosporine was used on kidney transplant recipients to improve graft survival in transplantation. Gingival overgrowth is a common complication of cyclosporine treatment after renal transplantation. The severity of gingival overgrowth seems to be related to the duration of treatment. Some studies reported that the increment of collagen and extracellular matrix affect the symptoms, but the actual mechanism of cyclosporine inducing the gingival overgrowth was not known yet. The substitute of cyclosporine has been introduced, cyclosporine is still the dominant immunosuppressant. So we hereby report 3 cases of gingival overgrowth induced by cyclosporine with review of literatures.
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