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Acute Severe Ulcerative Colitis: Optimal Strategies for Drug Therapy

Nakase H

Acute severe ulcerative colitis (ASUC) is a life-threatening medical emergency with considerable morbidity (30% to 40%). Patients with ASUC require hospitalization for prompt medical treatment, and colectomy is considered if...
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Two Cases of Pityriasis Rubra Pilaris after Cyclosporine Treatment

Kim JS, Lee JS, Koo DW

  • KMID: 2538566
  • Korean J Dermatol.
  • 2022 Dec;60(10):683-686.
Pityriasis rubra pilaris (PRP) is a rare chronic inflammatory papulosquamous disease of the skin. Its exact pathogenesis and incidence are not yet known. Clinically, it presents as palmoplantar keratoderma, hyperkeratotic...
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A Case of Rebound Phenomenon after Cessation of Cyclosporine for Guselkumab Therapy in Psoriasis

Park SH, Jung SY

  • KMID: 2538565
  • Korean J Dermatol.
  • 2022 Dec;60(10):679-682.
Cyclosporine is one of the main therapeutic agents for psoriasis. It is known that psoriasis relapses 2∼3 months after discontinuation of cyclosporine, and exacerbation due to abrupt discontinuation of cyclosporine...
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The Efficacies and Safeties of a 0.05% Cyclosporine Nanoemulsion and a 0.1% Cyclosporine Cationic Emulsion

Ji M, Choi CY, Kim SJ, Jeong J

Purpose: We evaluated the efficacy and safety of a 0.05% cyclosporine ophthalmic nanoemulsion and a 0.1% cyclosporine ophthalmic cationic emulsion in patients with moderate-to-severe dry-eye syndrome. Methods: This was a multi-center,...
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Adverse Events and Safety of Oral Cyclosporine for Dermatoses among Children and Adolescents: A Single Center Study

Kim YH, Han HJ, Kang HY, Park YJ, Choi JW

  • KMID: 2534009
  • Korean J Dermatol.
  • 2022 Sep;60(8):483-490.
Background: Cyclosporine (CS) is widely used in various dermatological diseases, and its range of usage has been expanded to younger patients. However, data on the safety of CS in children...
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The Association between Cumulative Dose of Cyclosporine and Renal Function Abnormality in Dermatology Patients Managed with Low Dose Regimen

Kim JW, Kim M, Kim BR, Youn SW

  • KMID: 2518984
  • Korean J Dermatol.
  • 2021 Jul;59(6):426-433.
Background: Cyclosporine (CsA), an immunosuppressant that specifically regulates T-lymphocytes, has long been used in dermatology practice. However, nephrotoxicity, a well-known adverse effect associated with high-dose (≥5 mg/kg/d) and long-term administration...
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A Retrospective Analysis of the Factors Affecting the Treatment Outcomes of Cyclosporine in Patients with Psoriasis

Choi YG, Lee HJ, Choi YJ, Kim WS, Lee GY

  • KMID: 2516139
  • Korean J Dermatol.
  • 2021 May;59(4):266-276.
Background: Cyclosporine is an effective drug for the treatment of psoriasis. Nonetheless, little is known about the factors associated with its effectiveness. Objective: This study aimed to analyze the factors affecting...
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Omalizumab for Cyclosporine-resistant Chronic Spontaneous Urticaria: A Retrospective Study of a Single Center

Kim HJ, Kim Wi, Shin K, Son JH, Lee WK, Kim HS, Kim B, Kim MB, Ko HC

  • KMID: 2514427
  • Korean J Dermatol.
  • 2021 Mar;59(3):175-180.
Background: Cyclosporine is a recommended third-line treatment for chronic spontaneous urticaria (CSU) that is resistant to H1-antihistamines according to the EAACI/GA 2 LEN/EDF/WAO guidelines for management of urticaria. However, some...
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Therapeutic Outcomes of Long-term Low-dose Systemic Cyclosporine Treatment in Patients with Chronic Alopecia Areata

Cho YR, Kim KH

  • KMID: 2506580
  • Korean J Dermatol.
  • 2020 Sep;58(8):505-511.
Background: Alopecia areata (AA) is a T cell-mediated autoimmune disease. In patients with chronic AA, hair loss occurs because of the insidious destruction of the stem cells in the hair...
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Effect of Cyclosporine A-induced Senescence on Cultured Human Corneal Endothelial Cells

Jang YK, Chung TY, Shin YJ

Purpose: To investigate the in vitro effect of cyclosporine A (CsA)-induced senescence on human corneal endothelial cells (HCECs). Methods: HCECs were cultured and incubated with 0-100 µM CsA. Senescence-associated β–galactosidase (SA-β-gal)...
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Urinary Concentration Defect and Renal Glycosuria in Cyclosporine-treated Rats

Lee JH, Kim SA, Jo CH, Lee CH, Kim GH

Background: Urinary concentration impairment is a major feature of cyclosporine nephrotoxicity. Methods: We explored two possible mechanisms that may underlie cyclosporineinduced polyuria; water, and/or osmotic diuresis. Cyclosporine was subcutaneously injected to...
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Characteristics and Management of Cyclosporine-associated Adverse Gastrointestinal Events

Koh WS, Ko YW, Kim JE, Ko JY, Ro YS

  • KMID: 2470214
  • Korean J Dermatol.
  • 2019 Dec;57(10):608-616.
BACKGROUND: Cyclosporine (CS) is widely used to treat various skin diseases. Gastrointestinal (GI) discomfort is the most common adverse effect of orally administered CS for dermatologic indications. However, few studies...
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Comparative Study of Quality of Life in Patients with Scalp Psoriasis Treated Using Topical Steroid Alone vs. Topical Steroid Combined with Cyclosporine

Kim M, Yang S, Kim BR, Youn SW

  • KMID: 2465915
  • Korean J Dermatol.
  • 2019 Nov;57(9):513-518.
BACKGROUND: Scalp psoriasis severely affects patients' quality of life, and patients may occasionally be refractory to topical steroid application. Although systemic therapy combined with topical steroid application is recommended for...
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Effectiveness of Cyclosporine-steroid Treatment after Cataract Surgery according to Dry Eye Severity

Park JY, Yang SC, Park YM, Lee JE, Park CY, Lee JS

PURPOSE: To evaluate the effectiveness of topically administered 0.05% cyclosporine combined with a topical steroid in the early postoperative period after cataract surgery, and to compare the therapeutic efficacy according...
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Development of a physiologically-based pharmacokinetic model for cyclosporine in Asian children with renal impairment

Yoon S, Yi S, Rhee SJ, Lee HA, Kim Y, Yu KS, Chung JY

This study aimed to assess the pharmacokinetics of cyclosporine A (CsA) in Asian children with renal impairment (RI) by developing a physiologically-based pharmacokinetic (PBPK) model with Simcyp Simulator. The PBPK...
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Factors Predicting the Response to Cyclosporin Treatment in Patients With Chronic Spontaneous Urticaria: A Systematic Review

Kulthanan , Subchookul C, Hunnangkul S, Chularojanamontri L, Tuchinda P

PURPOSE: This study aimed to systemically review literature relating to factors that could potentially predict a favorable response to cyclosporine A (CsA) treatment for chronic spontaneous urticaria (CSU). METHODS: A systematic...
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Efficacy of Topical Cyclosporine Nanoemulsion 0.05% Compared with Topical Cyclosporine Emulsion 0.05% and Diquafosol 3% in Dry Eye

Park CH, Kim MK, Kim EC, Kim JY, Kim TI, Kim HK, Song JS, Yoon KC, Lee DH, Lee HK, Chung TY, Choi CY, Kim HS

PURPOSE: To evaluate the efficacy and safety of cyclosporine nanoemulsion 0.05% compared to cyclosporine emulsion 0.05% and diquafosol sodium 3%. METHODS: This was a multicenter, randomized, evaluator-masked, active control, parallel, phase...
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Unilateral Deep Peroneal Neuropathy during Cyclosporine Therapy

Yoo JS, Kwon HS, Koh SH, Lee KY, Lee YJ, Choi H, Chung J

No abstract available.
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Comparison of Efficacy and Sensation of Instillation between 0.05% Cyclosporine Nanoemulsion and Microemulsion Type

Shin EH, Lim DH, Yang CM, Chung TY

PURPOSE: To evaluate and compare the efficacy and sensation of instillation between 0.05% cyclosporine nanoemulsion group and microemulsion group. METHODS: This is a double-blind, prospective randomized clinical trial. Patients had 2...
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Low-dose Acitretin and Cyclosporine Combination Therapy in Patients with Psoriasis: A Retrospective Analysis of 37 Cases

Gwak MJ, Kang IH, Shin MK, Kim NI

  • KMID: 2437069
  • Korean J Dermatol.
  • 2018 Dec;56(10):658-659.
No abstract available.
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