Clin Psychopharmacol Neurosci.  2011 Aug;9(2):86-90.

Effects of Sinapic Acid of 4 Vessel Occlusion Model-Induced Ischemia and Cognitive Impairments in the Rat

Affiliations
  • 1Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science, Rural Development Administration, Eumseong, Korea.
  • 2Department of Oriental Pharmaceutical Science and Kyung Hee East-West Pharmaceutical Research Institute, College of Pharmacy, Kyung Hee University, Seoul, Korea.
  • 3Department of Pharmacology, School of Medicine, Kangwon National University, Chuncheon, Korea. heejaelee@kangwon.ac.kr

Abstract


OBJECTIVE
Sinapic acid (SA, Sinapine), small naturally occurring hydroxycinnamic acid, has a GABA(A) receptor agonistic property and free radical scavenging activity. We examined potential neuroprotective effects of sinapic acid (SA) using global cerebral ischemia animal model.
METHODS
MTT assay was performed to determine cytotoxic effects of SA. To examine the neuroprotective effects of SA, SA was administrated for 14 d before 4-vessel occlusion. Also, to determine whether SA prevents cognitive impairment, Morris water maze was performed.
RESULTS
In this study, the efficacy of SA for the prevention of neuronal damage and for the reduction of memory impairment was investigated.
CONCLUSION
The results indicate that SA confers significant neuroprotection especially for ischemic hippocampal neurons.

Keyword

Sinapic acid; Neuroprotection effect; Memory; Hippocampus

MeSH Terms

Animals
Brain Ischemia
Coumaric Acids
Glycosaminoglycans
Hippocampus
Ischemia
Maze Learning
Memory
Neurons
Neuroprotective Agents
Rats
Receptors, GABA-A
Coumaric Acids
Glycosaminoglycans
Maze Learning
Neuroprotective Agents
Receptors, GABA-A
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