- Striatal CREB Phosphorylation Following Cued/Response Learning in the Water Maze Differ in Two Inbred Strains of Mice
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Hwang YK, Han JS
- KMID: 2165281
- Exp Neurobiol.
- 2008 Dec;17(2):41-46.
- doi: 10.5607/en.2008.17.2.41
Much evidence shows that the hippocampus and striatum play roles as important neural substrates for spatial/place and cued/response learning, respectively. This experiment was conducted to investigate the engagement of the... -
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- Inhibitory Effects of Eucommia ulmoides Oliv. Bark on Scopolamine-Induced Learning and Memory Deficits in Mice
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Kwon SH, Ma SX, Joo HJ, Lee SY, Jang CG
- KMID: 2170664
- Biomol Ther.
- 2013 Nov;21(6):462-469.
Eucommia ulmoides Oliv. Bark (EUE) is commonly used for the treatment of hypertension, rheumatoid arthritis, lumbago, and ischialgia as well as to promote longevity. In this study, we tested the... -
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- Enhancement of Short-Term Memory by Methyl-6-(Phenylethynyl)-Pyridine in the BTBR T+tf/J Mouse Model of Autism Spectrum Disorder
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Yang H, Huh SO, Hong JS
- KMID: 2407111
- Endocrinol Metab.
- 2015 Mar;30(1):98-104.
- doi: 10.3803/EnM.2015.30.1.98
BACKGROUND: Autism spectrum disorder (ASD) encompasses a range of disorders that are characterized by social and communication deficits and repetitive behaviors. This study evaluated the effect of methyl-6-(phenylethynyl)-pyridine (MPEP), an... -
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- Effects of Takju intake and moderate exercise training on brain acetylcholinesterase activity and learning ability in rats
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Kim B, Yang HJ, Chang MJ, Kim SH
- KMID: 2313531
- Nutr Res Pract.
- 2011 Aug;5(4):294-300.
Takju is a Korean alcoholic beverage made from rice, and is brewed with the yeast Saccharomyces cerevisiae. This study was conducted to evaluate the effects of exercise training and moderate... -
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- Protective Effect of Arabinoxylan against Scopolamine-Induced Learning and Memory Impairment
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Kim CY, Lee GY, Park GH, Lee J, Jang JH
- KMID: 2380326
- Biomol Ther.
- 2014 Sep;22(5):467-473.
- doi: 10.4062/biomolther.2014.063
The purpose of this study is to investigate the memory enhancing effect and underlying molecular mechanism of arabinoxylan (AX), a major component of dietary fiber in wheat against scopolamine (SCO)-induced... -
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- Amelioration of Cognitive Dysfunction in APP/PS1 Double Transgenic Mice by Long-Term Treatment of 4-O-Methylhonokiol
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Jung YY, Lee YJ, Choi DY, Hong JT
- KMID: 2170641
- Biomol Ther.
- 2014 May;22(3):232-238.
Alzheimer's disease (AD) is the most common neurodegenerative disease without known ways to cure. A key neuropathologic manifestation of the disease is extracellular deposition of beta-amyloid peptide (Abeta). Specific mechanisms... -
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- The Combination of Antidepressant Duloxetine with Piracetam in Mice does not Produce Enhancement of Nootropic Activity
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Kale PP, Addepalli , Sarkar A, Patel S, Savai J
- KMID: 2165526
- Exp Neurobiol.
- 2014 Sep;23(3):224-230.
- doi: 10.5607/en.2014.23.3.224
There is a strong association between depression and memory impairment. The present study aims to assess the nootropic activity of duloxetine and piracetam combination. Male Swiss Albino mice were divided... -
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- Effects of Sinapic Acid of 4 Vessel Occlusion Model-Induced Ischemia and Cognitive Impairments in the Rat
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Kim YO, Lee SW, Oh MS, Lee HJ
- KMID: 2171265
- Clin Psychopharmacol Neurosci.
- 2011 Aug;9(2):86-90.
OBJECTIVE: Sinapic acid (SA, Sinapine), small naturally occurring hydroxycinnamic acid, has a GABA(A) receptor agonistic property and free radical scavenging activity. We examined potential neuroprotective effects of sinapic acid (SA)... -
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- alpha-Asarone Ameliorates Memory Deficit in Lipopolysaccharide-Treated Mice via Suppression of Pro-Inflammatory Cytokines and Microglial Activation
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Shin JW, Cheong YJ, Koo YM, Kim S, Noh CK, Son YH, Kang C, Sohn NW
- KMID: 2048326
- Biomol Ther.
- 2014 Jan;22(1):17-26.
alpha-Asarone exhibits a number of pharmacological actions including neuroprotective, anti-oxidative, anticonvulsive, and cognitive enhancing action. The present study investigated the effects of alpha-asarone on pro-inflammatory cytokines mRNA, microglial activation, and... -
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- Effect of Codonopsis lanceolata with Steamed and Fermented Process on Scopolamine-Induced Memory Impairment in Mice
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Weon JB, Yun BR, Lee J, Eom MR, Ko HJ, Kim JS, Lee HY, Park DS, Chung HC, Chung JY, Ma CJ
- KMID: 2048312
- Biomol Ther.
- 2013 Sep;21(5):405-410.
Codonopsis lanceolata (Campanulaceae) traditionally have been used as a tonic and to treat patients with lung abscesses. Recently, it was proposed that the extract and some compounds isolated from C.... -
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- Alternations of Septal-hippocampal System in the Adult Wistar Rat with Spatial Memory Impairments Induced by Chronic Cerebral Hypoperfusion
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Choi BR, Kwon KJ, Park SH, Jeon WK, Han SH, Kim HY, Han JS
- KMID: 2052821
- Exp Neurobiol.
- 2011 Jun;20(2):92-99.
- doi: 10.5607/en.2011.20.2.92
In the current investigation, the status of the septo-hippocampal cholinergic pathway and hippocampal mitogen-activated protein kinase (MAPK) signaling was examined in male Wistar rats with chronic cerebral hypoperfusion, which showed... -
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- Effect of Regular Exercise Program on Cognitive Function in Chronic Cerebral Hypoperfused Rat
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Yun HS, Kim JK, Song MK, Seon HJ, Han JY, Choi IS, Lee SG
- KMID: 2048462
- Brain Neurorehabil.
- 2011 Sep;4(2):95-102.
- doi: 10.12786/bn.2011.4.2.95
OBJECTIVE: To investigate the effect of regular exercise program on cognitive function in chronic cerebral hypoperfused rat. METHOD: Forty-eight male Sprague-Dawley rats were used. Chronic cerebral hypoperfusion was induced by bilateral... -
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- Expression of the plant viral protease NIa in the brain of a mouse model of Alzheimer's disease mitigates Abeta pathology and improves cognitive function
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Kim TK, Han HE, Kim H, Lee JE, Choi D, Park WJ, Han PL
- KMID: 1402318
- Exp Mol Med.
- 2012 Dec;44(12):740-748.
The plant viral protease, NIa, has a strict substrate specificity for the consensus sequence of Val-Xaa-His-Gln, with a scissoring property after Gln. We recently reported that NIa efficiently cleaved the... -
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- The Effect of Combined Therapy of Exercise and Nootropic Agent on Cognitive Function in Focal Cerebral Infarction Rat Model
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Song MK, Seon HJ, Kim IG, Han JY, Choi IS, Lee SG
- KMID: 2266734
- Ann Rehabil Med.
- 2012 Jun;36(3):303-310.
- doi: 10.5535/arm.2012.36.3.303
OBJECTIVE: To investigate the effect of combined therapy of exercise and nootropic agent on cognitive function in a focal cerebral infarction rat model. METHOD: Forty 10-week old male Sprague-Dawley rats were... -
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- Ethanolic Extract of the Seed of Zizyphus jujuba var. spinosa Ameliorates Cognitive Impairment Induced by Cholinergic Blockade in Mice
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Lee HE, Lee SY, Kim JS, Park SJ, Kim JM, Lee YW, Jung JM, Kim DH, Shin BY, Jang DS, Kang SS, Ryu JH
- KMID: 2170676
- Biomol Ther.
- 2013 Jul;21(4):299-306.
In the present study, we investigated the effect of ethanolic extract of the seed of Zizyphus jujuba var. spinosa (EEZS) on cholinergic blockade-induced memory impairment in mice. Male ICR mice... -
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- Basal Forebrain Cholinergic Deficits Reduce Glucose Metabolism and Function of Cholinergic and GABAergic Systems in the Cingulate Cortex
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Jeong DU, Oh JH, Lee JE, Lee J, Cho ZH, Chang JW, Chang WS
- KMID: 2466366
- Yonsei Med J.
- 2016 Jan;57(1):165-172.
- doi: 10.3349/ymj.2016.57.1.165
PURPOSE: Reduced brain glucose metabolism and basal forebrain cholinergic neuron degeneration are common features of Alzheimer's disease and have been correlated with memory function. Although regions representing glucose hypometabolism in... -
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